Selected publications (2004~)

 

1.Otsubo T, Hagiwara T, Okamura T, Ishizaka Y, Kawamura YI, Dohi T. Retrotransposition of long interspersed nucleotide element-1 is associated with colitis but not tumors in a murine colitic cancer model PLOS ONE In press, 2015

2.Otsubo T, Hagiwara T, Tamura-Nakano M, Sezaki T, Miyake O, Hinohara C, Shimizu T, Yamada K, Dohi T, Kawamura YI. Aberrant DNA hypermethylation reduces the expression of the desmosome-related molecule periplakin in esophageal squamous cell carcinoma. Cancer Medicine, 2015

3.Kawamura YI, Adachi Y, Curiel DT, Kawashima R, Kannagi R, Nishimoto N, Dohi T. Therapeutic adenoviral gene transfer of a glycosyltransferase for prevention of peritoneal dissemination and metastasis of gastric cancer. Cancer Gene Ther 21:427-33, 2014

4.Dohi T, Kawashima R, Kawamura YI, Otsubo T, Hagiwara T, Amatucci A, Michaelson J, Burkly LC. Pathological activation of canonical nuclear-factor kappaB by synergy of tumor necrosis factor alpha and TNF-like weak inducer of apoptosis in mouse acute colitis. Cytokine 69:14-21, 2014

5.Yang L, Yamamoto K, Nishiumi S, Nakamura M, Matsui H, Takahashi S, Dohi T, Okada T, Kakimoto K, Hoshi N, Yoshida M, Azuma T. Interferon-gamma-producing B cells induce the formation of gastric lymphoid follicles after Helicobacter suis infection. Mucosal Immunol, 2014

6.Obata Y, Furusawa Y, Endo TA, Sharif J, Takahashi D, Atarashi K, Nakayama M, Onawa S, Fujimura Y, Takahashi M, Ikawa T, Otsubo T, Kawamura YI, Dohi T, Tajima S, Masumoto H, Ohara O, Honda K, Hori S, Ohno H, Koseki H, Hase K. The epigenetic regulator Uhrf1 facilitates the proliferation and maturation of colonic regulatory T cells. Nat Immunol 15:571-9, 2014

7.Anderson R et al. (FANTOM Consortium, RIKEN).  An atlas of active enhancers across human cell types and tissues. Nature 507:455-61, 2014

8.FANTOM Consortium and the RIKEN PMI and CLST (DGT). A promoter-level mammalian expression atlas. Nature 507:462-70, 2014

9.Oshio T, Kawashima R, Kawamura YI, Hagiwara T, Mizutani N, Okada T, Otsubo T, Inagaki-Ohara K, Matsukawa A, Haga T, Kakuta S, Iwakura Y, Hosokawa S, Dohi T. Chemokine Receptor CCR8 Is Required for Lipopolysaccharide-Triggered Cytokine Production in Mouse Peritoneal Macrophages. PLOS ONE 9:e94445, 2014

10.Said HS, Suda W, Nakagome S, Chinen H, Oshima K. Kim S. Kimura R, Iraha A, Ishida H, Fujita J, Mano S, Morita H, Dohi T, Oota H, Hattori M. Dysbiosis of Salivary Microbiota in Inflammatory Bowel Disease and Its Association With Oral Immunological Biomarkers. DNA Research; 21:15-25, 2014

11.Inagaki-Ohara K, Mayuzumi H, Kato S, Minokoshi Y, Otsubo T, Kawamura YI, Dohi T, Matsuzaki G, Yoshimura A. Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice. Oncogene; 33:74-84, 2014

12.Sugiura T, Kageyama S, Andou A, Miyazawa T, Ejima C, Nakayama A, Dohi T, Eda H. Oral treatment with a novel small molecule alpha 4 integrin antagonist, AJM300, prevents the development of experimental colitis in mice. J Crohns Colitis, 7:e533-42, 2013

13.Iijima K. Okudaira N, Tamura M, Doi A, Saito Y, Shimura M, Goto M, Matsunaga A, Kawamura YI, Otsubo T, Dohi T, Hoshino S, Kano S, Hagiwara S, Tanuma J, Gatanaga H, Baba M, Iguchi T, Yanagita M, Oka S, Okamura T, Ishizaka Y. Viral protein R of human immunodeficiency virus type-1 induces retrotransposition of long interspersed element-1. Retrovirology;10:83, 2013

14.Son A, Oshio T, Kawamura YI, Hagiwara T, Yamazaki M, Inagaki-Ohara K, Okada T, Wu P, Iseki M, Takaki S, Burkly LC, Dohi T. TWEAK/Fn14 pathway promotes a T helper 2-type chronic colitis with fibrosis in mice. Mucosal Immunology, 6: p. 1131-1142, 2013.

15.Okada T, Fukuda S, Hase K, Nishiumi S, Izumi Y, Yoshida M, Hagiwara T, Kawashima R, Yamazaki M, Oshio T, Otsubo T, Inagaki-Ohara K, Kakimoto K, Higuchi K, Kawamura YI, Ohno H, Dohi. T. Microbiota derived lactate accelerates colon epithelial cell turnover in starvation-refed mice. Nature Communications 4:1654, 2013

16.Tsubokawa D, Goso Y, Kawashima R, Ota H, Nakamura T, Nakamura K, Sato N, Kurihara M, Dohi T, Kawamura YI, Ichikawa T, Ishihara K. The monoclonal antibody HCM31 specifically recognises the Sda tetrasaccharide in goblet cell mucin. FEBS Open Bio;2:223-233, 2012

17.Miyazaki K, Sakuma K, Kawamura YI, Izawa M, Ohmori K, Mitsuki M, Yamaji T, Hashimoto Y, Suzuki A, Saito Y, Dohi T, Kannagi R. Colonic epithelial cells express specific ligands for mucosal macrophage immunosuppressive receptors siglec-7 and -9. J Immunol;188:4690-700, 2012

18.Dohi T, Burkly LC. The TWEAK/Fn14 pathway as an aggravating and perpetuating factor in inflammatory diseases; focus on inflammatory bowel diseases. J Leukoc Biol, 92:265-279, 2012

19.Kawashima R, Kawamura YI, Oshio T, Mizutani N, Okada T, Kawamura YJ, Konishi F, Dohi T. Comprehensive analysis of chemokines and cytokines secreted in the peritoneal cavity during laparotomy. J Immunoassay Immunochem 2011141:2119-2129 2012.

20.Kawashima R, Kawamura YI, Oshio T, Son A, Yamazaki M, Hagiwara T, Okada T, Inagaki-Ohara K, Wu P, Szak S, Kawamura YJ, Konishi F, Miyake O, Yano H, Saito Y, Burkly LC, Dohi T. Interleukin-13 Damages Intestinal Mucosa via TWEAK and Fn14 in Mice - a Pathway Associated with Ulcerative Colitis. Gastroenterology 2011;141:2119-2129.

21.Inagaki-Ohara K, Sakamoto Y, Dohi T, Smith AL. Gamma-delta T cells play a protective role during infection with Nippostrongylus brasiliensis by promoting goblet cell function in the small intestine. Immunology 2011;134:448-58.

22.Takahashi D, Hase K, Kimura S, Nakatsu F, Ohmae M, Mandai Y, Sato T, Date Y, Ebisawa M, Kato T, Obata Y, Fukuda S, Kawamura YI, Dohi T, Katsuno T, Yokosuka O, Waguri S, Ohno H. The epithelia-specific membrane trafficking factor AP-1B controls gut immune homeostasis in mice. Gastroenterology 2011;141:621-32.

23.Burkly LC, Dohi T. The TWEAK/Fn14 Pathway in Tissue Remodeling: For Better or for Worse. Adv Exp Med Biol 2011;691:305-322.

24.Watanabe-Takahashi M, Sato T, Dohi T, Noguchi N, Kano F, Murata M, Hamabata T, Natori Y, Nishikawa K. An orally applicable Shiga toxin neutralizer functions in the intestine to inhibit the intracellular transport of the toxin. Infect Immun 2010;78:177-183

25.Dohi T, Borodovsky A, Wu P, Shearstone JR, Kawashima R, Runkel L, Rajman L, Dong X, Scott ML, Michaelson JS, Jakubowski A, Burkly LC. TWEAK/Fn14 Pathway: a nonredundant role in intestinal damage in mice through a TWEAK/intestinal epithelial cell axis. Gastroenterology 136:912-923, 2009.

26.Kawamura, YI, Toyota M, Kawashima R, Hagiwara T, Suzuki H, Imai K, Shinomura Y, Tokino T, Kannagi R, and Dohi T, DNA hypermethylation contributes to incomplete synthesis of carbohydrate determinants in gastrointestinal cancer Gastroenterology, 135:142-151, 2008

27.Dohi T and Kawamura YI, Incomplete synthesis of the Sd(a)/Cad blood group carbohydrate in gastrointestinal cancer. Biochim Biophys Acta, 1780:467-471, 2008

28.Mizutani N, Sakurai T, Shibata T, Uchida K, Fujita J, Kawashima R, Kawamura Y. I., Toyama-Sorimachi N, Imai T, Dohi T. Dose-dependent, differential regulation of cytokine secretion from macrophages by fractalkineJ. Immunol 79:7478-7487, 2007

29.Hoshino, A, Kawamura YI, Yasuhara M, Toyama-Sorimachi N, Yamamoto K, and Dohi T, Aggregation of peritoneal macrophages via CCL1/CCR8 triggers inflammatory and postoperative adhesion. J. Immunol., 178:5296-5304, 2007

30.Osawa, E, Nakajima A, Fujisawa T, Kawamura YI, Toyama-Sorimachi N, Nakagama H, and Dohi T, Predominant T Helper Type 2-Inflammatory Responses Promote Murine Colon Cancers. Int J Cancer, 118:2232-2236, 2006

31.Maemura, K, Yanagawa Y, Obata K, Dohi T, Egashira Y, Shibayama Y, and Watanabe M, Antigen presenting cells expressing glutamate decarboxylase 67 were identified as epithelial cells in glutamate decarboxylase 67-GFP knock-in mouse thymus. Tissue Antigens, 67:198-206, 2006

32.Kunisaki, R, Ikawa S, Maeda T, Nakazaki Y, Kurita R, Harata M, Shutoh Y, Bai Y, Soda Y, Tanabe T, Dohi T, Kato R, Ikawa Y, Sekihara H, Asano S, and Tani K, p51/p63, a novel p53 homologue, potentiates p53 activity and is a human cancer gene therapy candidate. J. Gene Med., 8:1121-1130, 2006

33.Kawashima, R, Kawamura YI, Kato R, Mizutani N, Toyama-Sorimachi N, and Dohi T, IL-13 receptor 2 promotes epithelial cell regeneration from radiation-induced small intestinal injury in mice. Gastroenterology, 131:130-141, 2006

34.Kanai, T, Kawamura T, Dohi T, Makita S, Nemoto Y, Totsuka T, and Watanabe M, TH1/TH2-Mediated Colitis Induced by Adoptive Transfer of CD4+CD45RBhigh T Lymphocytes Into Nude Mice. Inflamm Bowel Dis, 12:89-99, 2006

35.Hagiwara, Y, Kawamura YI, Kataoka K, Rahima B, Jackson RJ, Komase K, Dohi T, Boyaka PN, Takeda Y, Kiyono H, McGhee JR, and Fujihashi K, A Second generation of double mutant cholera toxin adjuvants: enhanced immunity without intracellular trafficking. J Immunol, 177:3045-3054, 2006

36.Dohi T and Fujihashi K, Type 1 and 2 T helper cell-mediated colitis. Current Opinion in Gastroenterology, 22:651-657, 2006

37.Kawamura, YI, Kawashima R, Fukunaga R, Hirai K, Toyama-Sorimachi N, Tokuhara M, Shimizu T, and Dohi T, Introduction of Sd(a) carbohydrate antigen in gastrointestinal cancer cells eliminates selectin ligands and inhibits metastasis. Cancer Res, 65:6220-6227, 2005

38.Dohi T, Ejima C, Kato R, Kawamura YI, Kawashima R, Mizutani N, Tabuchi Y, and Kojima I, Therapeutic potential of follistatin for colonic inflammation in mice. Gastroenterology, 128:411-423, 2005

39.Tsujimura, Y, Kikuchi-Maki A, Dohi T, Onoda A, Koyasu S, Inaba K, Karasuyama H, and Toyama-Sorimachi N, Ly49Q1 is Expressed on Myeloid Lineage Cells and Involved in Regulation of Cell Adhesiveness. 1. Immunology 2004 published by International Conference of Immunology. 2004. 187-191.

40.Shirasawa, S, Sugiyama S, Baba I, Inokuchi J, Sekine S, Ogino K, Kawamura YI, Dohi T, Fujimoto M, and Sasazuki T, Epiregulin-deficiency results in dermatitis and critical role of epiregulin in immune-related responses of keratinocyte and macrophage. Proc. Natl. Acad. Sci. U. S. A., 101:13921-13926, 2004

41.Shirai, Y, Hashimoto M, Kato R, Kawamura YI, Kirikae T, Yano H, Takashima J, Kirihara Y, Saito Y, Fujino MA, and Dohi T, Lipopolysaccharide induces CD25-positive, IL-10-producing lymphocytes without secretion of proinflammatory cytokines in the human colon: Low MD-2 mRNA expression in the colonic macrophages. J. Clin. Immunol., 24:42-52, 2004

42.Kawamura, T, Kanai T, Dohi T, Uraushihara K, Totsuka T, Iiyama R, Taneda C, Yamazaki M, Okamoto R, Nakamura T, Higuchi T, Aiba Y, Tsubata T, and Watanabe M, Expansion of ectopic CD40 ligand-expressing B cells and development of chronic colitis in mice. J Immunol, 172:6388-6397, 2004

43.Dohi T, Fujihashi K, Koga T, Etani Y, Yoshino N, Kawamura YI, and McGhee JR, CD4+CD45RBHi inteleukin-4 defective T cells elicit antral gastritis and duodenitis. Am. J. Pathol., 165:1257-1268, 2004