論文業績Presented Paper

  1. Nawaz A, Aminuddin A, Kado T, Takikawa A, Yamamoto S, Tsuneyama K,Igarashi Y, Ikutani M, Nishida Y, Nagai Y, Takatsu K, Imura J, Sasahara M,Okazaki Y, Ueki K, Okamura T, Tokuyama K, Ando A, Matsumoto M, Mori H, Nakagawa T, Kobayashi N, Saeki K, Usui I, Fujisaka S, Tobe K. CD206 + M2-like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adipocyte progenitors.Nat. Commun. Vol 8, 286, 2017
  2. Yudasaka, M., Yomogida, Y., Zhang, M., Tanaka, T., Nakahara, M., Kobayashi,N., Okumatsu-Ogura, Y., Machida, K., Ishihara, K., Saeki, K. and Katakura, H.Near-Infrared Photoluminescent Carbon Nanotubes for Imaging of Brown Fat.Sci. Rep. 7, 44760, 2017
  3. Kobayashi, N., Nakahara, M., Oka, M. and Saeki, K.Could ”Brown Adipose Tissue Failure” be a Cause of Metabolic Syndrome ?”Med. Res. Archive 4, v4, 2016
  4. Nishio M, Nakahara M, Yuo A, Saeki K: Human pluripotent stem cells:Towards therapeutic development for the treatment of lifestyle diseases.World J Stem Cells. 8: 56–61, 2016
  5. Nishio M, Nakahara M, Sato C, Saeki K, Akutsu H, Umezawa A, Tobe K,Yasuda K, Yuo A, Saek K: New categorization of human vascular endothelial cells by pro- vs anti-proliferative phenotypes. World J Transl Med 4: 88-100,2015.
  6. Nakahara M, Nishio M, Saeki K, Yuo A, Saeki K: p38 mitogen-activated protein kinase regulates type-I vs type-II phenotyping of human vascular endothelial cells. World J Transl Med 4: 101-112, 2015.
  7. Nishio M, Nakahara M, Saeki K, Fujiu K, Iwata H, Manabe I, Yuo A, Saeki K:Pro- vs anti-stenotic capacities of type-I vs type-II human induced pluripotent-derived endothelial cells. World J Transl Med 4: 113-122, 2015.
  8. Nishio M, Yoneshiro T, Nakahara M, Suzuki S, Saeki K, Hasegawa M, Kawai Y, Akutsu H, Umezawa A, Yasuda K, Tobe K, Yuo A, Kubota K, Saito M, Saeki K: Production of functional classical brown adipocytes from human pluripotent stem cells using specific hemopoietin cocktail without gene transfer. Cell Metab 16:394-406, 2012.
  9. Nakamura N, Saeki K, Mitsumoto M, Matsuyama S, Nishio M, Saeki K, Hasegawa M, Miyagawa Y, Ohkita H, Kiyokawa N, Toyoda M, Akutsu H, Umezawa A, Yuo A: Feeder-free and serum-free production of hepatocytes, cholangiocytes, and their proliferating progenitors from human pluripotent stem cells: application to liver-specific functional and cytotoxic assays. Cell Reprogram 14:171-185, 2012.
  10. Gokoh M, Nakamura N, Matsuyama S, Nishio M, Akutsu H, Umezawa A, Yasuda K, Yuo A, Saeki K: Early senescence is not an inevitable fate of human induced pluripotent stem-derived cells. Cell Reprogram 13:361-370, 2011.
  11. Saeki K, Saeki K, Nakahara M, Matsuyama S, Nakamura N, Yogiashi Y, Yoneda A, Koyanagi M, Kondo Y, Yuo A: A feeder-free and efficient production of functional neutrophils from human embryonic stem cells. Stem Cells 27:59-67, 2009.
  12. Nakahara M, Saeki K, Nakamura N, Matsuyama S, Yogiashi Y, Yasuda K, Kondo Y, Yuo A: Human embryonic stem cells with maintenance under a feeder-free and recombinant cytokine-free condition. Cloning Stem Cells 11:5-18, 2009.
  13. Nakahara M, Nakamura N, Matsuyama S, Yogiashi Y, Yasuda K, Kondo Y, Yuo A, Saeki K: High efficiency production of subculturable vascular endothelial cells from feeder-free human embryonic stem cells without cell-sorting technique. Cloning Stem Cells 11:509-522, 2009.
  14. Yokoyama T, Miyazawa K, Naito M, Toyotake J, Tauchi T, Itoh M, Yuo A, Hayashi Y, Georgescu MM, Kondo Y, Kondo S, Ohyashiki K: Vitamin K2 induces autophagy and apoptosis simultaneously in leukemia cells. Autophagy 4:629-640, 2008.
  15. Saeki K, Yogiashi Y, Nakahara M, Nakamura N, Matsuyama S, Koyanagi A, Yagita H, Koyanagi M, Kondo Y, Yuo A: Highly efficient and feeder-free production of subculturable vascular endothelial cells from primate embryonic stem cells. J Cell Physiol 217:261-280, 2008.
  16. Nakahara M, Matsuyama S, Saeki K, Nakamura N, Saeki K, Yogiashi Y, Yoneda A, Koyanagi M, Kondo Y, Yuo A: A feeder-free hematopoietic differentiation system with generation of functional neutrophils from feeder and cytokine-free primate embryonic stem cells. Cloning Stem Cells 10:341-354, 2008.
  17. Nakai-Murakami C, Shimura M, Kinomoto M, Takizawa Y, Tokunaga K, Taguchi T, Hoshino S, Miyagawa K, Sata T, Kurumizaka H, Yuo A, Ishizaka Y: HIV-1 Vpr induces ATM-dependent cellular signal with enhanced homologous recombination. Oncogene 26:477-486, 2007.
  18. Nakahara M, Saeki K, Yogiashi Y, Kimura A, Horiuchi A, Nakamura N, Yoneda A, Saeki K, Matsuyama S, Nakamura M, Toda T, Kondo Y, Kaburagi Y, Yuo A: The protein expression profile of cynomolgus monkey embryonic stem cells in two-dimensional gel electrophoresis: a successful identification of multiple proteins using human databases. J Electrophoresis 51:1-8, 2007.
  19. Yasugi E, Horiuchi A, Uemura I, Okuma E, Nakatsu M, Saeki K, Kamisaka Y, Kagechika H, Yasuda K, Yuo A: Peroxisome proliferator-activated receptor γ ligands stimulate myeloid differentiation and lipogenensis in the human leukemia NB4 cells. Dev Growth Differ 48:177-188, 2006.
  20. Doshi M, Koyanagi M, Nakahara M, Saeki K, Saeki K, Yuo A: Identification of human neutrophils during experimentally induced inflammation in mice transplanted with human umbilical cord blood CD34-positive cells. Int J Hematol 84:231-237, 2006.
  21. Nakatsu M, Doshi M, Saeki K, Yuo A: Synergistic effects of dehydroepiandrosterone and retinoic acid on granulocytic differentiation of human promyelocytic NB4 cells. Int J Hematol 81:32-38, 2005.
  22. Yano T, Itoh Y, Kubota T, Sendo T, Koyama T, Fujita T, Saeki K, Yuo A, Oishi R: A prostacyclin analog prevents radiocontrast nephropathy via phosphorylation of cyclic AMP response element binding protein. Am J Pathol 166:1333-1342, 2005.
  23. Saeki K, Yasugi E, Okuma E, Breit SN, Nakamura M, Toda T, Kaburagi Y, Yuo A: Proteomic analysis on insulin signaling in human hematopoietic cells: identification of CLIC1 and SRp20 as novel downstream effectors of insulin. Am J Physiol Endocrinol Metab 289:E419-E428, 2005.
  24. Horiuchi A, Yasugi E, Yuo A: Structural requirement of dolichyl phosphate as an apoptosis inducer. J Oleo Science 54:341-346, 2005.
  25. Asada M, Ohmi K, Delia D, Enosawa S, Suzuki S, Yuo A, Suzuki H, Mizutani S: Brap2 functions as a cytoplasmic retention protein for p21 during monocytic differentiation. Mol Cell Biol 24:8236-8243, 2004.
  26. Inazawa Y, Saeki K, Yuo A: Granulocyte colony-stimulating factor-induced terminal maturation of human myeloid cells is specifically associated with up-regulation of receptor-mediated function and CD10 expression. Int J Hematol 7:142-151, 2003.
  27. Saeki K, Saeki K, Yuo A: Distinct involvement of cAMP-response element-dependent transcriptions in functional and morphological maturation during retinoid-mediated human myeloid differentiation. J Leukoc Biol 73:673-681, 2003.
  28. Kobayashi N, Saeki K, Yuo A: Granulocyte-macrophage colony-stimulating factor and interleukin 3 induce cell cycle progression through the synthesis of c-Myc protein by internal ribosome entry site-mediated translation via phosphatidylinositol 3-kinase pathway in human factor-dependent leukemic cells. Blood 102:3186-3195, 2003.
  29. Saeki K, Zhang H, Nakatsu M, Yoshimori T, Kabeya Y, Yamamoto A, Kaburagi Y, Yuo A: Insulin-dependent signaling regulates azurophil granule-selective macroautophagy in human myeloblastic cells. J Leukoc Biol 74:1108-1116, 2003.
  30. Inazawa Y, Nakatsu M, Yasugi E, Saeki K, Yuo A: Lipid droplet formation in human myeloid NB4 cells stimulated by all trans retinoic acid and granulocyte colony-stimulating factor: possible involvement of peroxisome proliferator-activated receptor γ. Cell Struct Funct 28:487-493, 2003.
  31. Saeki K, Okuma E, Yuo A: Recurrent growth factor starvation promotes drug resistance in human leukaemic cells. Brit J Cancer 86:292-300, 2002.
  32. Yasugi E, Uemura I, Kumagai T, Nishikawa Y, Yasugi S, Yuo A: Disruption of mitochondria is an early event during dolichyl monophosphate-induced apoptosis in U937 cells. Zool Sci 19:7-13, 2002.
  33. Okuma E, Inazawa Y, Saeki K, Yuo A: Potential roles of extracellular-signal regulated kinase (ERK) but not p38 during myeloid differentiation of U937 cells stimulated by cytokines: augmentation of differentiation via prolonged activation of ERK. Exp Hematol 30:571-581, 2002.
  34. Saeki K, Kobayashi N, Inazawa Y, Zhang H, Nishitoh H, Ichijo H, Saeki K, Isemura M, Yuo A: Oxidation-triggered c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein (MAP) kinase pathways for apoptosis in human leukemic cells stimulated by epigallocatechin-3-gallate (EGCG): a distinct pathway from those of chemically-induced and receptor-mediated apoptosis. Biochem J 368:705-720, 2002.
  35. Hagiwara S, Yagisawa M, Iki S, Mimura T, Urabe A, Miwa A, Togawa A, Higashihara M, Takaku F, Yuo A: Tyrosine phosphorylation of proteins in primary human myeloid leukemic cells stimulated by macrophage colony-stimulating factor: analysis by disease types and comparison with normal human hematopoietic cells. Int J Hematol 73:100-107, 2001.
  36. Saeki K, Yuo A, Koizumi M, Fujiwara K, Kaneko M, Takaku F, Yazaki Y: CREB antisense oligonucleotides induce non-apoptotic cell death in proliferating leukemia cells, but not normal hematopoietic cells, by a bizarre non-antisense mechanism. Leukemia 15:238-245, 2001.
  37. Miyazawa K, Yaguchi M, Funato K, Gotoh A, Kawanishi Y, Nishizawa Y, Yuo A, Ohyashiki K: Apoptosis/differentiation-inducing effects of vitamin K2 on HL-60 cells: dichotomous nature of vitamin K2 in leukemia cells. Leukemia 15:1111-1117, 2001.
  38. Hayakawa S, Saeki K, Sazuka M, Suzuki Y, Shoji Y, Ohta T, Kaji K, Yuo A, Isemura M: Apoptosis induction by epigallocatechin gallate involves its binding to fas. Biochem Biophys Res Commun 285:1102-1106, 2001.
  39. Inoue Y, Yagisawa M, Saeki K, Imajoh-Ohmi S, Kanegasaki S, Yuo A: Induction of phagocyte oxidase components during human myeloid differentiation: independent protein expression and discrepancy with the function. Biosci Biotechnol Biochem 5:2581-2584, 2001.
  40. Belmonte N, Phillips BW, Massiera F, Villageois P, Wdziekonski B, Saint-Marc P, Nichols J, Aubert J, Saeki K, Yuo A, Narumiya S, Ailhaud G, Dani C: Activation of extracellular signal-regulated kinases and CREB/ATF-1 mediate the expression of CCAAT/enhancer binding proteins β and δ in preadipocytes. Mol Endocrinol 15:2037-2049, 2001.
  41. Saeki K, Yagisawa M, Kitagawa S, Yuo A: Diverse effects of cytochalasin B on priming and triggering of the respiratory burst activity in human neutrophils. Int J Hematol 74:409-415, 2001.
  42. Saeki K, Yuo A, Okuma E, Yazaki Y, Susin SA, Kroemer G, Takaku F: Bcl-2 down-regulation causes autophagy in a caspase-independent manner in human leukemic HL-60 cells. Cell Death Differ 7:1263-1269, 2000.
  43. Saeki K, Yuo A, Abe I, Seki T, Noguchi H, Isemura M: Apoptosis-inducing activity of lipid derivatives of gallic acid. Biol Pharm Bull 23:1391-1394, 2000.
  44. Yasugi E, Kumagai T, Nishikawa Y, Okuma E, Saeki K, Oshima M, Susin SA, Kroemer G, Yuo A: Involvement of apoptosis-inducing factor during dolichyl monophosphate-induced apoptosis in U937 cells. FEBS Lett 480:197-200, 2000.
  45. Okuma E, Saeki K, Shimura M, Ishizaka Y, Yasugi E, Yuo A: Induction of apoptosis in human hematopoietic U937 cells by granulocyte-macrophage colony-stimulating factor: possible existence of caspase 3-like pathway. Leukemia 14:612-619, 2000.
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