news & Topics

  • HOME>
  • news & Topix

News & Topics

November 20, 2012

Students of Shonan Gakuen High School visited IDL.
They studied recent progress of HIV-1 research and drug screening.

Students of Shonan Gakuen High School

November 16, 2012

he small molecule activator to ACE2 prevents the inhibition of ACE2 activity by autoantibodies
ACR/ARHP Annual Meeting, Washington, D.C., U. S. A. November 10-14, 2012

膠原病科との共同研究の成果をワシントンD.C.で開催された米国リウマチ学会で発表しました。
We previously reported that autoantibody to ACE2 was frequently detected in patients of SLE patients,
and autoantibody inhibited the activity of angiotensin converting enzyme 2 (ACE2)
(Takahashi et al., Arthritis Res Ther. 2010;12: R85)。
Here, we found that a reported ACE2 activator(XNT)ameliorated the inhibitory activity of the autoantibody
to ACE2.

IgG of the patients inhibited ACE2 activity

IgG of the patients inhibited ACE2 activity

positive rate of inhibition of ACE2 activity by IgG
with vasculopathy; 10 of 13 patients ⇒ 76.9%
w/o vasculopathy; 3 of 11 patients ⇒ 27.3%

XNT ameliorated an inhibitory activity of the patients IgG

XNT ameliorated an inhibitory activity of the patients IgG
ResearchProject
  • Integration of HIV-1 at DNA double strands break site
  • Mode of respiratory distress by SARS-CoV
  • Autoantibodies in patients of collagen diseases
  • Novel peptide vector developed at NCGM
  • Retrotransposition of endogenous retroelements
  • Visualization of intracellular elements
  • Genomic instability by HIV-1 infection