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Intractable Diseases

Research Topic

Research Interests:

Research Interests in Division of Intractable Diseases

Research Interests in Division of Clinical Immunology

Natural killer cells are critical for both innate and adaptive immunity. NK cells play important roles in elimination of virally infected cells and tumors. NK cell functions are regulated by the opposing signals from activating or inhibitory receptors. Our laboratory has focused on activating and inhibitory receptors on NK cells and T cells. Recently, we found that NKG2D, an activating receptor, are important for viral immunity, tumor immunity and the development of autoimmune diabetes. Therefore, we will explore that the molecular mechanisms underlying recognition of NK cells and T cells against target cells in viral immunity, tumor immunity and autoimmunity.



Main Staff (Ishizaka Group)

Director Yukihito Ishizaka
Special Fellow Kenta Iijima
Tomoki Takashina
Research Fellow Shiori Haga
Takuya Tada

Main Staff (Shimura Group)

Chief, Section of Intractable Diseases Mari Shimura
Research Fellow Miwa Nakano
Reiko Ooba
Akihiro Matsunaga
Research Institute
Diabetes Research Center
The Research Center for Hepatitis and Immunology
Project Research
National Center for Global Health and Medicin
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