Publications and etc.

Publications


Lysosome biogenesis regulated by the amino-acid transporter SLC15A4 is critical for functional integrity of mast cells.
Kobayashi T, Tsutsui H, Shimabukuro-Demoto S, Sugitani-Yoshida R, Karyu H, Furuyama-Tanaka K, Ohshima D, Kato N, Okamura T, Toyama-Sorimachi N.
Int Immunol. (in press)

A Novel Role for PHT1 in the Disposition of L-Histidine in Brain: In Vitro Slice and In Vivo Pharmacokinetic Studies in Wildtype and Pht1 Null Mice.
Wang XX, Hu Y, Keep RF, Toyama-Sorimachi N, Smith DE.
Biochem Pharmacol. 2016 Nov 11. pii: S0006-2952(16)30399-9. doi: 10.1016/j.bcp.2016.11.012.

Separation of Intracellular Vesicles for Immunoassays.
Kobayashi T, Tanaka T, and Toyama-Sorimachi N.
Bio-protocol 5(16): e1571.
http://www.bio-protocol.org/e1571

The assembly of EDC4 and Dcp1a into processing bodies is critical for the translational regulation of IL-6.
Seto E, Yoshida-Sugitani R, Kobayashi T, Toyama-Sorimachi N.
PLoS One 2015 May 13;10(5):e0123223. doi: 10.1371/journal.pone.0123223.

Roles of ADAM8 in elimination of injured muscle fibers prior to skeletal muscle regeneration.
Nishimura D, Sakai H, Sato T, Sato F, Nishimura S, Toyama-Sorimachi N, Bartsch JW, Sehara-Fujisawa A.
Mech Dev. 2015 Feb;135:58-67. doi: 10.1016/j.mod.2014.12.001.

The Histidine Transporter SLC15A4 Coordinates mTOR-dependent Inflammatory Responses and Pathogenic Antibody Production
Kobayashi T, Shimabukuro-Demoto S, Yoshida-Sugitani R, Furuyama-Tanaka K, Karyu H, Sugiura Y, Shimizu Y, Hosaka T, Goto M, Kato N, Okamura T, Suematsu M, Yokoyama S, Toyama-Sorimachi N.
Immunity. 2014 Sep 18; 41(3):375-388. doi: 10.1016/j.immuni.2014.08.011.
表紙


Autoantibodies to IgG/HLA class II complexes are associated with rheumatoid arthritis susceptibility.
Jin H, Arase N, Hirayasu K, Kohyama M, Suenaga T, Saito F, Tanimura K, Matsuoka S, Ebina K, Shi K, Toyama-Sorimachi N, Yasuda S, Horita T, Hiwa R, Takasugi K, Ohmura K, Yoshikawa H, Saito T, Atsumi T, Sasazuki T, Katayama I, Lanier LL, Arase H.
Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3787-92. doi: 10.1073/pnas.1401105111. Epub 2014 Feb 24.

How do cells optimize luminal environments of endosomes/lysosomes for efficient inflammatory responses?
Kobayashi T, Tanaka T, Toyama-Sorimachi N. J Biochem. 2013 Dec;154(6):491-9. doi: 10.1093/jb/mvt099. Epub 2013 Oct 31.

Specific mtDNA mutations in mouse carcinoma cells suppress their tumor formation via activation of the host innate immune system.
Imanishi H, Takibuchi G, Kobayashi T, Ishikawa K, Nakada K, Mori M, Kikkawa Y, Takenaga K,Toyama-Sorimachi N, Hayashi J. PLoS One. 2013 Sep 30;8(9):e75981. doi: 10.1371/journal.pone.0075981.

Polymorphic mutations in mouse mitochondrial DNA regulate a tumor phenotype.
Takibuchi G, Imanishi H, Morimoto M, Ishikawa K, Nakada K, Toyama-Sorimachi N, Kikkawa Y, Takenaga K, Hayashi J. Mitochondrion. 2013 Nov;13(6):881-7. doi: 10.1016/j.mito.2013.07.117. Epub 2013 Aug 6.

A clonogenic progenitor with prominent plasmacytoid dendritic cell developmental potential.
Onai N, Kurabayashi K, Hosoi-Amaike M, Toyama-Sorimachi N, Matsushima K, Inaba K, Ohteki T. Immunity. 2013 May 23;38(5):943-57. doi: 10.1016/j.immuni.2013.04.006. Epub 2013 Apr 25.

Ly49Q positively regulates type I IFN production by plasmacytoid dendritic cells in an immunoreceptor tyrosine-based inhibitory motif-dependent manner.
Rahim MM, Tai LH, Troke AD, Mahmoud AB, Abou-Samra E, Roy JG, Mottashed A, Ault N, Corbeil C, Goulet ML, Zein HS, Hamilton-Valensky M, Krystal G, Kerr WG, Toyama-Sorimachi N, Makrigiannis AP. J Immunol. 2013 Apr 15;190(8):3994-4004. doi: 10.4049/jimmunol.1200873. Epub 2013 Mar 11.

Spi-B is critical for plasmacytoid dendritic cell function and development.
Sasaki I, Hoshino K, Sugiyama T, Yamazaki C, Yano T, Iizuka A, Hemmi H, Tanaka T, Saito M, Sugiyama M, Fukuda Y, Ohta T, Sato K, Ainai A, Suzuki T, Hasegawa H, Toyama-Sorimachi N, Kohara H, Nagasawa T, Kaisho T. Blood. 2012 Dec 6;120(24):4733-43.

The solute carrier family 15A4 regulates TLR9 and NOD1 functions in the innate immune system and promotes colitis in mice.
Sasawatari S, Okamura T, Kasumi E, Tanaka-Furuyama K, Yanobu-Takanashi R, Shirasawa S, Kato N, Toyama-Sorimachi N.
Gastroenterology. 2011 May;140(5):1513-25.

The innate immune system in host mice targets cells with allogenic mitochondrial DNA.
Ishikawa K, Toyama-Sorimachi N, Nakada K, Morimoto M, Imanishi H, Yoshizaki M, Sasawatari S, Niikura M, Takenaga K, Yonekawa H, Hayashi J.
J Exp Med. 2010 Oct 25;207(11):2297-305.

Dynamic distribution of muscle-specific calpain in mice has a key role in physical-stress adaptation and is impaired in muscular dystrophy.
Ojima K, Kawabata Y, Nakao H, Nakao K, Doi N, Kitamura F, Ono Y, Hata S, Suzuki H, Kawahara H, Bogomolovas J, Witt C, Ottenheijm C, Labeit S, Granzier H, Toyama-Sorimachi N, Sorimachi M, Suzuki K, Maeda T, Abe K, Aiba A, Sorimachi H.
J Clin Invest. 120(8):2672-83, 2010

Calpain 8/nCL-2 and calpain 9/nCL-4 constitute an active protease complex, G-calpain, involved in gastric mucosal defense.
Hata, S., Abe, M., Suzuki, H., Kitamura, F., Toyama-Sorimachi, N., Abe, K., Sakimura, K., and Sorimachi, H.
PLoS Genetics 6:e1001040, 2010

Ly49Q, an ITIM-bearing NK receptor, positively regulates osteoclast differentiation.
Hayashi M, Nakashima T, Kodama T, Makrigiannis AP, Toyama-Sorimachi N, Takayanagi H.
Biochem Biophys Res Commun. 393:432-438, 2010

The Ly49Q receptor plays a crucial role in neutrophil polarization and migration by regulating raft trafficking.
Sasawatari S, Yoshizaki M, Taya C, Tazawa A, Furuyama-Tanaka K, Yonekawa H, Dohi T, Makrigiannis AP, Sasazuki T, Inaba K, Toyama-Sorimachi N.
Immunity. 2010 Feb 26;32(2):200-13.

Spatiotemporal regulation of intracellular trafficking of Toll-like receptor 9 by an inhibitory receptor, Ly49Q.
Yoshizaki M, Tazawa A, Kasumi E, Sasawatari S, Itoh K, Dohi T, Sasazuki T, Inaba K, Makrigiannis AP, Toyama-Sorimachi N.
Blood. 2009 Aug 20;114(8):1518-27.

Positive regulation of plasmacytoid dendritic cell function via Ly49Q recognition of class I MHC.
Tai LH, Goulet ML, Belanger S, Toyama-Sorimachi N, Fodil-Cornu N, Vidal SM, Troke AD, McVicar DW, Makrigiannis AP.
J Exp Med. 2008 Dec 22;205(13):3187-99.

Presentation

89th Annual Meeting of Japanese Society for Bacteriology
[Mar 2016, Osaka, Japan]
Handa Y, Toyama-Sorimachi N.
Role of inhibitory receptor Ly49Q on SCV formation and inflammatory response triggered by Salmonella
[Poster]

44th Annual meeting of Japan Society for Immunology
[Nov 2015, Sapporo, Japan].

Kobayashi T, Ohshima D, Toyama-Sorimachi N.
The Histidine transporter SLC15A4 regulates allergic responses by tuning the endo/lysosomal condition of mast cells.
[Oral/Poster]

Machida A, Kobayashi T, Toyama-Sorimachi N.
A possible involvement of endo-exocytosis coupling machinery in granule-dependent NK cytotoxicity.
[Poster]

Handa Y, Toyama-Sorimachi N.
A cis-interacting MHC class I receptor, Ly49Q mediates macropinocytic uptake of extracellular antigens.
[Oral/Poster]

Toyama-Sorimachi N, Handa Y.
MHC class I and its cis-interacting receptor shape GPCR signaling platform and orchestrate neutrophil chemotaxis.
[Oral/Poster]


43rd Annual meeting of Japan Society for Immunology
[Dec 2014, Kyoto, Japan].

Kobayashi T, Toyama-Sorimachi N.
SLC15A4 regulates TLR7/9-triggered type I interferon responses coordinating mTORC activity at lysosome.
[Oral/Poster]

Toyama-Sorimachi N, Kobayashi T.
A lysosomal oligopeptide transporter SLC15A4 regulates homeostasis and inflammatory responses of mast cells.
[Poster]

Handa Y, Toyama-Sorimachi N.
An ITIM-bearing receptor Ly49Q regulates actin cytoskeleton by controlling Rac activity.
[Oral/Poster]