支援実例ギャラリー｜国立国際医療研究センター研究所

トップページ > 研究部紹介 > 共通実験室 > 支援実例ギャラリー

透過型電子顕微鏡JEM-1400作例

拡大で表示
New! PC-9細胞
GA・オスミウム酸で二重固定し、EMステイナー（日新EM）で染色、凍結乾燥を施すことで、微細構造がより詳細に観察できるようになりました。
（電顕支援・尾山研究員）
拡大で表示
マクロファージ
（分子炎症制御プロジェクト・半田先生ご提供）

（注：平成22から平成24は「形態観察共同利用システム」として受注したものを含む）

依頼案件・検体数推移

Fatty acyl-chain remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport.
Hashidate-Yoshida T, Harayama T, Hishikawa D, Morimoto R, Hamano F, Tokuoka SM, Eto M, Tamura-Nakano M, Yanobu-Takanashi R, Mukumoto Y, Kiyonari H, Okamura T, Kita Y, Shindou H, Shimizu T. eLIFE. 2015 Apr 21;4. doi: 10.7554/eLife.06328. [Epub ahead of print] PubMed PMID: 25898003.
Aberrant DNA hypermethylation reduces the expression of the desmosome-related molecule periplakin in esophageal squamous cell carcinoma.
Otsubo T, Hagiwara T, Tamura-Nakano M, Sezaki T, Miyake O, Hinohara C, Shimizu T, Yamada K, Dohi T, Kawamura YI. Cancer Med. 2015 Mar;4（3）:415-25. doi: 10.1002/cam4.369. Epub 2015 Jan 12. PubMed PMID: 25583674; PubMed Central PMCID: PMC4380967.

Integrative omics analysis reveals differentially loaded proteins in dimorphic euspermatozoa of the squid, Loligo bleekeri.
Yoshida MA, Yamada L, Ochi H, Iwata Y, Tamura-Nakano M, Sawada H, Sauer WH, Ogura A, Hirohashi N. Biochem Biophys Res Commun. 2014 Aug 1;450（3）:1218-24. doi: 10.1016/j.bbrc.2014.04.076. Epub 2014 Apr 24.
Cilostazol improves lymphatic function by inducing proliferation andstabilization of lymphatic endothelial cells.
Kimura T, Hamazaki TS, Sugaya M, Fukuda S, Chan T, Tamura-Nakano M, Sato S, Okochi H. J Dermatol Sci. 2014 Jan 21.

Transcription factors interfering withdedifferentiation induce cell type-specific transcriptional profiles.
Hikichi T, Matoba R, Ikeda T, Watanabe A, Yamamoto T, Yoshitake S, Tamura-Nakano M, Kimura T, Kamon M, Shimura M, Kawakami K, Okuda A, Okochi H, Inoue T, Suzuki A, Masui S. ProcNatlAcadSci U S A. 2013 Apr 16;110（16）:6412-7

The Histidine Transporter SLC15A4 Coordinates mTOR-Dependent Inflammatory Responses and Pathogenic Antibody Production.
Kobayashi T, Shimabukuro-Demoto S, Yoshida-Sugitani R, Furuyama-Tanaka K, Karyu H, Sugiura Y, Shimizu Y, Hosaka T, Goto M, Kato N, Okamura T, Suematsu M, Yokoyama S, Toyama-Sorimachi N. Immunity 2014 Sep 18;41（3）:375-88. doi: 10.1016/j.immuni.2014.08.011.
MafA is critical for neonatal proliferation of pancreatic β-cells.
Eto K, Nishimura W, Oishi H, Udagawa H, Kawaguchi M, Hiramoto M, Fujiwara T, Takahashi S, Yasuda K. PLoS One. 2014 Aug 15;9（8）:e104184. doi: 10.1371/journal.pone.0104184. eCollection 2014.

Quantitative assessment of Pdx1 promoter activity in vivo using a secreted luciferase reporter system.
Wataru Nishimura, Koki Eto, Atsushi Miki, Motohito Goto, Miho Kawaguchi, Takao Nammo, Haruhide Udagawa, Masaki Hiramoto, Yukiko Shimizu, Tadashi Okamura, Toshiyoshi Fujiwara, Yoshikazu Yasuda, and Kazuki Yasuda. Endocrinology 2013 Nov;154（11）:4388-95.
Transcription factors interfering with dedifferentiation induce cell type-specific transcriptional profiles.
Hikichi T, Matoba R, Ikeda T, Watanabe A, Yamamoto T, Yoshitake S, Tamura-Nakano M, Kimura T, Kamon M, Shimura M, Kawakami K, Okuda A, Okochi H, Inoue T, Suzuki A, Masui S. Proc Natl Acad Sci U S A. 2013 Apr 16;110（16）:6412-7.

Enhancement of leptin receptor signaling by SOCS3 deficiency induces development of gastric tumors in mice.
Inagaki-Ohara K, Mayuzumi H, Kato S, Minokoshi Y, Otsubo T, Kawamura YI, Dohi T, Matsuzaki G, Yoshimura A. Oncogene. 2012 Nov 26. doi: 10.1038/onc.2012.540.
Deletion of CDKAL1 affects high-fat diet-induced fat accumulation and glucose-stimulated insulin secretion in mice, indicating relevance to diabetes.
Okamura T, Yanobu-Takanashi R, Takeuchi F, Isono M, Akiyama K, Shimizu Y, Goto M, Liang YQ, Yamamoto K, Katsuya T, Fujioka A, Ohnaka K, Takayanagi R, Ogihara T, Yamori Y, Kato N. PLoS One 2012;7（11）:e49055. doi: 10.1371/journal.pone.0049055. Epub 2012 Nov 16.