発表論文

2017

1. Tada T, Shimada K, Mya S, Zan KN, Kuwahara K, Kirikae T, Tin HH : A new variant of 16S rRNA methylase, RmtD3, in a clinical isolate of Pseudomonas aeruginosa in Myanmar. Antimicrob Agents Chemother. 2017 Oct 30. pii: AAC.01806-17. doi: 10.1128/AAC.01806-17. [Epub ahead of print]
2. Uechi K, Tada T, Shimada K, Nakasone I, Sonozaki T, Kirikae T, Fujita J : Emergence of ArmA, a 16S rRNA methylase in highly aminoglycoside-resistant clinical isolates of Klebsiella pneumoniae and Klebsiella oxytoca in Okinawa, Japan. J Infect Chemother. 2017 Oct 21. pii: S1341-321X(17)30208-8. doi: 10.1016/j.jiac.2017.09.006. [Epub ahead of print]
3. Shrestha B, Tada T, Shimada K, Shrestha S, Ohara H, Pokhrel BM, Sherchand JB, Kirikae T : Emergence of various NDM-type metalo-ß-lactamase-producing Escherichia coli clinical isolates in Nepal. Antimicrob Agents Chemother. 2017 Oct 9. pii: AAC.01425-17. doi: 10.1128/AAC.01425-17. [Epub ahead of print]
4. Tada T, Tsuchiya M, Shimada K, Nga TTT, Thu LTA, Phu TT, Ohmagari N, Kirikae T : Dissemination of carbapenem-resistant Klebsiella pneumoniae clinical isolates with various combinations of carbapenemases (KPC-2, NDM-1, NDM-4, and OXA-48) and 16S rRNA methylases (RmtB and RmtC) in Vietnam. BMC Infect Dis. 2017 Jul 4;17(1):467. doi: 10.1186/s12879-017-2570-y.
5. Tada T, Shimada K, Satou K, Hirano T, Pokhrel BM, Sherchand JB, Kirikae T : Pseudomonas aeruginosa clinical isolates in Nepal coproducing metallo-ß-lactamases and 16S rRNA methyltransferases. Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00694-17. doi: 10.1128/AAC.00694-17. Print 2017 Sep.
6. Tada T, Nhung PH, Shimada K, Tsuchiya M, Phuong DM, Anh NQ, Ohmagari N, Kirikae T : Emergence of colistin-resistant Escherichia coli clinical isolates harboring mcr-1 in Vietnam. Int J Infect Dis. 2017 Oct;63:72-73. doi: 10.1016/j.ijid.2017.07.003. Epub 2017 Jul 10.
7. Tada T, Uechi K, Nakasone I, Shimada K, Nakamatsu M, Kirikae T, Fujita J : Emergence of a colistin-resistant Escherichia coli clinical isolate harboring mcr-1 in Japan. Int J Infect Dis. 2017 Oct;63:21-22. doi: 10.1016/j.ijid.2017.07.023. Epub 2017 Aug 2.
8. Uechi K, Tada T, Shimada K, Kuwahara-Arai K, Arakaki M, Tome T, Nakasone I, Maeda S, Kirikae T, Fujita J : A Modified Carbapenem inactivation method, CIMTris, for carbapenemase production in Acinetobacter and Pseudomonas Species. J Clin Microbiol. 2017 Sep 27. pii: JCM.00893-17. doi: 10.1128/JCM.00893-17. [Epub ahead of print]
9. Tamehiro N, Nishida K, Yanobu-Takanashi R, Goto M, Okamura T, Suzuki H : T-cell activation RhoGTPase-activating protein plays an important role in TH17-cell differentiation. Immunol Cell Biol. 2017 Sep;95(8):729-735. doi: 10.1038/icb.2017.27. Epub 2017 May 2.
10. Sezaki T, Hirata Y, Hagiwara T, Kawamura YI, Okamura T, Takanashi R, Nakano K, Tamura-Nakano M, Burkly LC, Dohi T : Disruption of the TWEAK/Fn14 pathway prevents 5-fluorouracil-induced diarrhea in mice. World J Gastroenterol. 2017 Apr 7;23(13):2294-2307. doi: 10.3748/wjg.v23.i13.2294.
11. Nagashima K, Sawa S, Nitta T, Tsutsumi M, Okamura T, Penninger JM, Nakashima T, Takayanagi H : Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota. Nat Immunol. 2017 Jun;18(6):675-682. doi: 10.1038/ni.3732. Epub 2017 Apr 24.
12. Iizuka-Hishikawa Y, Hishikawa D, Sasaki J, Takubo K, Goto M, Nagata K, Nakanishi H, Shindou H, Okamura T, Ito C, Toshimori K, Sasaki T, Shimizu T : Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis. J Biol Chem. 2017 Jul 21;292(29):12065-12076. doi: 10.1074/jbc.M117.791277. Epub 2017 Jun 3.
13. Nitta T, Kochi Y, Muro R, Tomofuji Y, Okamura T, Murata S, Suzuki H, Sumida T, Yamamoto K, Takayanagi H : Human thymoproteasome variations influence CD8 T cell selection. Sci Immunol. 2017 Jun 2;2(12). pii: eaan5165. doi: 10.1126/sciimmunol.aan5165. Epub 2017 Jun 2.
14. Nawaz A, Aminuddin A, Kado T, Takikawa A, Yamamoto S, Tsuneyama K, Igarashi Y, Ikutani M, Nishida Y, Nagai Y, Takatsu K, Imura J, Sasahara M, Okazaki Y, Ueki K, Okamura T : CD206+ M2-like macrophages regulate glucose metabolism by inhibiting proliferation of adipocyte progenitors. Nat Commun. 2017 Aug 18;8(1):286. doi: 10.1038/s41467-017-00231-1.
15. Ogura K, Watanabe S, Kirikae T, Miyoshi-Akiyama T : Complete Genome Sequence and Comparative Genomics of a Streptococcus pyogenes emm3 Strain M3-b isolated from a Japanese Patient with Streptococcal Toxic Shock Syndrome. J Genomics. 2017 Jul 1;5:71-74. doi: 10.7150/jgen.20915. eCollection 2017.
16. Tada T, Tsuchiya M, Shimada K, Nga TTT, Thu LTA, Phu TT, Ohmagari N, Kirikae T : Dissemination of Carbapenem-resistant Klebsiella pneumoniae clinical isolates with various combinations of Carbapenemases (KPC-2, NDM-1, NDM-4, and OXA-48) and 16S rRNA Methylases (RmtB and RmtC) in Vietnam. BMC Infect Dis. 2017 Jul 4;17(1):467. doi: 10.1186/s12879-017-2570-y.
17. Mizukoshi F, Miyoshi-Akiyama T, Iwai H, Suzuki T, Kiritani R, Kirikae T, Funatogawa K : Genetic diversity of Mycobacterium tuberculosis isolates from Tochigi prefecture, a local region of Japan. BMC Infect Dis. 2017 May 25;17(1):365. doi: 10.1186/s12879-017-2457-y.
18. Suzuki-Yamazaki N, Yanobu-Takanashi R, Okamura T, Takaki S : IL-10 production in murine IgM+ CD138hi cells is driven by Blimp-1 and downregulated in class-switched cells. Eur J Immunol. 2017 Mar;47(3):493-503. doi: 10.1002/eji.201646549. Epub 2017 Jan 10.
19. Takahashi E, Hiroyuki Unoki-Kubota H, Yukiko Shimizu Y, Okamura T, Iwata W, Kajio H, Yamamoto-Honda R, Shiga T, Yamashita S, Tobe K, Okumura A, Matsumoto M, Yasuda K, Noda M and Kaburagi Y : Proteomic analysis of serum biomarkers for prediabetes using the Long-Evans Agouti rat, a spontaneous animal model of type 2 diabetes mellitus. J Diabetes Investig. 2017 Sep;8(5):661-671. doi: 10.1111/jdi.12638. Epub 2017 Mar 27.
20. Nihira NT, Ogura K, Shimizu K, North BJ, Zhang J, Gao D, Inuzuka H, Wei W : Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function. Sci Signal. 2017 Feb 14;10(466). pii: eaai8026. doi: 10.1126/scisignal.aai8026.
21. Shimizu K, Fukushima H, Ogura K, Lien EC, Nihira NT, Zhang J, North BJ, Guo A, Nagashima K, Nakagawa T, Hoshikawa S, Watahiki A, Okabe K, Yamada A, Toker A, Asara JM, Fukumoto S, Nakayama KI, Nakayama K, Inuzuka H, Wei W : The SCFß-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis. Sci Signal. 2017 Jan 3;10(460). pii: eaah4117. doi: 10.1126/scisignal.aah4117.
22. Ogura K, Terasaki Y, Miyoshi-Akiyama T, Terasaki M, Moss J, Noda M, Yahiro K : Vibrio cholerae Cholix toxin-induced HepG2 cell death is enhanced by tumor necrosis factor-alpha through ROS and intracellular signal-regulated kinases. Toxicol Sci. 2017 Apr 1;156(2):455-468. doi: 10.1093/toxsci/kfx009.
23. Tada T, Shrestha S, Shimada K, Ohara H, Sherchand JB, Pokhrel BM, Kirikae T : PER-8, a Novel Extended-Spectrum-ß-Lactamase PER Variant, from an Acinetobacter baumannii Clinical Isolate in Nepal. Antimicrob Agents Chemother. 2017 Feb 23;61(3). pii: e02300-16. doi: 10.1128/AAC.02300-16. Print 2017 Mar.
24. Sato T, Hamabata T, Takita E, Matsui T, Sawada T, Imaoka T, Nakanishi N, Nakayama K, Tsukahara T : Improved porcine model for Shiga toxin-producing Escherichia coli infection by deprivation of colostrum feeding in newborn piglets. Anim Sci J. 2017 May;88(5):826-831. doi: 10.1111/asj.12769. Epub 2017 Feb 1.

2016

1. Debnath A, Sabui S, Wajima T, Hamabata T, Baberjee R, Ramamurthy T, Chatterjee NS: Functional role of N- and C-terminal amino acids in the structural subunits of colonization factor CS6 expressed by enterotoxigenic Escherichia coli. J Bacteriol. 2016 Apr 14;198(9):1429-41. doi: 10.1128/JB.00657-15. Print 2016 May.
2. Tsukasaki M, Hamada K, Okamoto K, Nagashima K, Terashima A, Komatsu N, Win S, Okamura T, Nitta T, Yasuda H, Penninger JM, Takayanagi H.: LOX fails to substitute for RANKL in osteoclastogenesis. J Bone Miner Res.2017 Mar;32(3):434-439. doi: 10.1002/jbmr.2990. Epub 2016 Oct 3.
3. Ishikura S, Tsunoda T, Nakabayashi K, Doi K, Koyanagi M, Hayashi K, Kawai T, Tanaka Y, Iwaihara Y, Luo H, Nishi K, Okamura T, Shirasawa S : Molecular mechanisms of transcriptional regulation by the nuclear zinc-finger protein Zfat in T cells.Biochim Biophys Acta.2016 Nov;1859(11):1398-1410. doi: 10.1016/j.bbagrm.2016.08.010. Epub 2016 Aug 31.
4. Miyoshi-Akiyama T, Sherchan JB, Doi Y, Nagamatsu M, Sherchand JB, Tandukar S, Ohmagari N, Kirikae T, Ohara H, Hayakawa K: Comparative Genome Analysis of Extended-Spectrum-ß-Lactamase-Producing Escherichia coli Sequence Type 131 Strains from Nepal and Japan. mSphere. 2016 Oct 26;1(5). pii: e00289-16. eCollection 2016 Sep-Oct.
5. Hayakawa K, Mezaki K, Sugiki Y, Nagamatsu M, Miyoshi-Akiyama T, Kirikae T, Kutsuna S, Takeshita N, Yamamoto K, Katanami Y, Ohmagari N: High rate of multidrug-resistant organism colonization among patients hospitalized overseas highlights the need for preemptive infection control. American Journal of Infection Control. 2016 Nov 1;44(11):e257-e259. doi: 10.1016/j.ajic.2016.06.040.
6. Tada T, Nhung PH, Miyoshi-Akiyama T, Shimada K, Tsuchiya M, Phuong DM, Anh NQ, Ohmagari N, Kirikae T: Multidrug-Resistant Sequence Type 235 Pseudomonas aeruginosa Clinical Isolates Producing IMP-26 with Increased Carbapenem-Hydrolyzing Activities in Vietnam.Antimicrob Agents Chemother. 2016 Oct 21;60(11):6853-6858.
7. Matsumura K, Iwai H, Kato-Miyazawa M, Kirikae F, Zhao J, Yanagawa T, Ishii T, Miyoshi-Akiyama,T, Funatogawa K, Kirikae T: Peroxiredoxin 1 contributes to host defenses against Mycobacterium tuberculosis. J Immunol. 2016 Oct 15;197(8):3233-3244. Epub 2016 Sep 7.4
8. Watanabe S, Matsumura K, Iwai H, Funatogawa K, Haishima Y, Fukui C, Okumura K, Kato-Miyazawa M, Hashimoto M, Teramoto K, Kirikae F, Miyoshi-Akiyama T, Kirikae T: A mutation in the 16S rRNA decoding region attenuates the vrulence of Mycobacterium tuberculosis. Infect Immun. 2016 Jul 21;84(8):2264-73.
9. Kawamura Y, Tomida J, Miyoshi-Akiyama T, Okamoto T, Narita M, Hashimoto K, Cnockaert M, Vandamme P, Morita Y, Sawa T, Akaike T: Proposal of Helicobacter canicola sp. nov., previously identified as Helicobacter cinaedi, isolated from canines.Syst Appl Microbiol.2016 Jul;39(5):307-12. doi: 10.1016/j.syapm.2016.06.004. Epub 2016 Jun 25.
10. Sugiyama K, Sasano T, Kurokawa J, Takahashi K, Okamura T, Kato N, Isobe M, Furukawa T.: Oxidative Stress Induced Ventricular Arrhythmia and Impairment of Cardiac Function in Nos1ap Deleted Mice.Int Heart J. 2016 May 25;57(3):341-9.
11. Ishikura S, Iwaihara Y, Tanaka Y, Luo H, Nishi K, Doi K, Koyanagi M, Okamura T, Tsunoda T, Shirasawa S.: The Nuclear Zinc Finger Protein Zfat Maintains FoxO1 Protein Levels in Peripheral T Cells by Regulating the Activities of Autophagy and the Akt Signaling Pathway. J. Biol. Chem. 291,15282-15291 (2016) doi: 10.1074/jbc.M116.723734 May 20
12. Marusugi K, Nakano K, Sasaki H, Kimura J, Yanobu-Takanashi R, Okamura T, Sasaki N.: Functional validation of tensin2 SH2-PTB domain by CRISPR/Cas9-mediated genome editing. J. Vet .Med. Sci. 78, 1413-1420 (2016) doi:10.1292/jvms.16-0205 May 30
13. Shrestha S, Tada T, Shrestha B, Kirikae T, Ohara H, Rijal BP, Pokhrel BM, Sherchand JB: Emergence of Aminoglycoside Resistance Due to armA methylase in Multi-drug Resistant Acinetobacter Baumannii Isolates in a University Hospital in Nepal. J Nepal Health Res Counc. 2016 May;14(33):72-76.
14. Tada T, Miyoshi-Akiyama T, Shimada K, Shiroma A, Nakano K, Teruya K, Satou K, Hirano T, Shimojima M, Kirikae T: A carbapenem-Rresistant Pseudomonas aeruginosa isolate harboring two copies of blaIMP-34 encoding a metallo-ß-lactamase. PLoS One. 2016 Apr 7;11(4):e0149385.
15. Matono T, Hayakawa K, Hirai R, Tanimura A, Yamamoto K, Fujiya Y, Mawatari M, Kutsuna S, Takeshita N, Mezaki K, Ohmagari N, Miyoshi-Akiyama T: Emergence of a daptomycin-non-susceptible Enterococcus faecium strain that encodes mutations in DNA repair genes after high-dose daptomycin therapy. BMC Res Notes. 2016 Apr 1;9(1):197.
16. Watanabe S, Takemoto N, Ogura K, Miyoshi-Akiyama T: Severe invasive streptococcal infection by Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis. Microbiol and Immunol. 2016 Jan;60(1):1-9. doi: 10.1111/1348-0421.12334.

2015

1. Iwai H, Kato-Miyazawa M, Kirikae T, Miyoshi-Akiyama T: CASTB (The comprehensive analysis server for the Mycobacterium tuberculosis complex): a publicly accessible web server for epidemiological analyses, drug-resistance prediction and phylogenetic comparison of clinical isolates. Tuberculosis.95 (6): 843-844, 2015.
2. Tada T, Miyoshi-Akiyama T, Shimada K, Nga TT, Thu le TA, Son NT, Ohmagari N, Kirikae T: Dissemination of clonal complex 2 Acinetobacter baumannii strains co-producing carbapenemases and 16S rRNA methylase ArmA in Vietnam. BMC Infect Dis. 15:433, 2015.
3. Shrestha B, Shrestha S, Mishra SK, Kattel HP, Tada T, Ohara H, Kirikae T, Rijal BP, Sherchand JB, Pokhrel BM: Phenotypic characterization of multidrug-resistant Escherichia Coli with special reference to extended-spectrum-beta-lactamases and metallo-beta-lactamases in a tertiary care center. JNMA J Nepal Med Assoc. Apr-Jun;53(198):89-95, 2015.
4. Oshiro S, Tada T, Kameoka Y, Suzuki K, Ohmagari N, Miyoshi-Akiyama T, Kirikae T: Development and evaluation of immunochromatography to detect gram-negative bacteria producing ArmA 16S rRNA methylase responsible for aminoglycoside resistance. J Microbiol Methods. 118: 159-163, 2015.
5. Tada T, Nhung PH, Miyoshi-Akiyama T, Shimada K, Phuong DM, Anh NQ, Ohmagari N, Kirikae T: IMP-51, a novel IMP-type metallo-ß-lactamase with increased doripenem and meropenem hydrolyzing activities, in a carbapenem-resistant Pseudomonas aeruginosa clinical isolate. Antimicrob Agents Chemother. 59 (11): 7090-7093, 2015.
6. Shrestha S, Tada T, Miyoshi-Akiyama T, Ohara H, Shimada K, Satou K, Teruya K, Nakano K, Shiroma A, Sherchand JB, Rijal BP, Hirano T, Kirikae T*, Pokhrel BM : Molecular epidemiology of multidrug-resistant Acinetobacter baumannii isolates in a university hospital in Nepal reveals the emergence of a novel epidemic clonal lineage. Int J Antimicrob Agents.46(5): 526-531, 2015. *corresponding author.
7. Tada T, Miyoshi-Akiyama T, Shimada K, Dahal RK, Mishra SK, Ohara H, Kirikae T*, Pokhrel BM: A novel 6′-N-aminoglycoside acetyltransferase, AAC(6′)-Ial, from a clinical isolate of Serratia marcescens. Microb Drug Resist. 22(2):103-108, 2015. in press. *corresponding author.
8. Shrestha B, Tada T, Miyoshi-Akiyama T, Shimada K, Ohara H, Kirikae T*, Pokhrel BM: Identification of a novel NDM variant, NDM-13, from a multidrug-resistant Escherichia coli clinical isolate in Nepal. Antimicrob Agents Chemother. 59(9): 5847-5850, 2015. Shrestha B and Tada T contributed equally to this work. *corresponding author.
9. Nhung PH, Miyoshi-Akiyama T, Phuong DM, Shimada K, Anh NQ, Binh NG, Thanh DV, Ohmagari N, Kirikae T: Evaluation of the Etest method for detecting colistin susceptibility of multidrug-resistant Gram-negative isolates in Vietnam. J Infect Chemother. 21(8): 617-619, 2015.
10. Iwai H, Funatogawa K, Matsumura K, Kato-Miyazawa M, Kirikae F, Kiga K, Sasakawa C, Miyoshi-Akiyama T, Kirikae T: MicroRNA-155 knockout mice are susceptible to Mycobacterium tuberculosis infection. Tuberculosis. 95(3): 246-250, 2015.
11. Sabui S, Debnath A, Ghosal A, Wajima T, Hamabata T, Ramamurthy T, Ghosh AN, Basak S, Chatterjee NS: Characterization of oligomeric assembly of colonization factor CS6 from enterotoxigenic Escherichia coli. Microbiology.2015 Sep 16. [Epub ahead of print]
12. Sherchan JB, Hayakawa K, Miyoshi-Akiyama T, Ohmagari N, Kirikae T, Nagamatsu M, Masayoshi T, Toji M, Ohara H, Sherchand JB, Sarmila Tandukar S: Clinical epidemiology and molecular analysis of extended-spectrum ß-lactamase-producing Escherichia coli in Nepal: characteristics of sequence types ST131 and ST648, Antimicrob Agents Chemother. 2015 Mar 30. [Epub ahead of print]
13. Senoh M, Hamabata T, Takeda Y: A factor converting viable but nonculturable Vibrio cholerae to a culturable state in eukaryotic cells is a human catalase. Microbiologyopen. (4):589-596, 2015.
14. Hattori T, Watanabe-Takahashi M, Ohoka N, Hamabata T, Furukawa K, Nishikawa K, Naito M: Proteasome inhibitors prevent cell death and prolongs survival of mice challenged by Shiga toxin. FEBS Open Bio.5:605-614, 2015.
15. Iwaihara Y, Ishikura S, Doi K, Tsunoda T, Fujimoto T, Okamura T, Shirasawa S: Marked reduction in FoxO1 protein by its enhanced proteasomal degradation in Zfat-deficient peripheral T-cells. Anticancer Res.35(8):4419-4423, 2015.
16. Hashidate-Yoshida T, Harayama T, Hishikawa D, Morimoto R, Hamano F, Tokuoka SM, Eto M, Tamura-Nakano M, Yanobu-Takanashi R, Mukumoto Y, Kiyonari H, Okamura T, Kita Y, Shindou H, Shimizu T Fatty acid remodeling by LPCAT3 enriches arachidonate in phospholipid membranes and regulates triglyceride transport. eLife. 4: e06328, 2015.
17. Nitta T, Muro R, Shimizu Y, Nitta S, Oda H, Ohte Y, Goto M, Yanobu-Takanashi R, Narita T, Takayanagi H, Yasuda H, Okamura T, Murata S, Suzuki H: The thymic cortical epithelium determines the TCR repertoire of IL-17-producing γ δ T cells. EMBO Rep. 16(5): 638-653, 2015.
18. Otsubo T, Okamura T, Hagiwara T, Ishizaka Y, Dohi T, Kawamura YI: Retrotransposition of long interspersed nucleotide element-1 is associated with colitis but not tumors in a murine colitic cancer model. PLoS One. 10(2): e0116072, 2015.
19. Ishikura S, Ogawa M, Doi K, Matsuzaki H, Iwaihara Y, Tanaka Y, Tsunoda T, Hideshima H, Okamura T, Shirasawa S: Zfat-Deficient CD4(+) CD8(+) double-positive thymocytes are susceptible to apoptosis with deregulated activation of p38 and JNK. J Cell Biochem. 16(1): 149-57, 2015.
20. Debnath A, Wajima T, Sabui S, Hamabata T, Ramamurthy T, Chatterjee NS. Two specific amino acid variations in colonization factor CS6 subtypes of enterotoxigenic Escherichia coli results in differential binding and pathogenicity. Microbiology. 198(9):1429-1441, 2015. Debnath A and Wajima Tcontributed equally to this work.
21. Miyoshi-Akiyama T, Satou K, Kato M, Shiroma A, Matsumura K, Tamotsu H, Iwai H, Teruya K, Funatogawa K, Hirano T, Kirikae T: Complete annotated genome sequence of Mycobacterium tuberculosis (Zopf) Lehmann and Neumann (ATCC35812) (Kurono). Tuberculosis. 95(1): 37-39, 2015.
22. Okumura K, Kato M, Kirikae, T, Kayano M, Miyoshi-Akiyama T: Construction of a virtual Mycobacterium tuberculosis consensus genome and its application to data from a next generation sequencer. BMC Genomics. 16(1): 218, 2015.
23. Kato-Miyazawa M, Miyoshi-Akiyama T, Kanno Y, Takasaki J, Kirikae T, Kobayashi N: Genetic diversity of Mycobacterium tuberculosis isolates from foreign-born and Japan-born residents in Tokyo. Clin Microbiol infect. 21(3): 248.e1-248.e8, 2015
24. Tojo M, Mawatari M, Hayakawa K, Nagamatsu M, Shimada K, Mezaki K, Sugiki Y, Kuroda E, Takeshita N, Kutsuna S, Fujiya Y, Miyoshi-Akiyama T, Kirikae T, Ohmagari N: Multidrug-resistant Acinetobactor baumannii isolated from a traveler returned from Brunei. J Infect Chemother. 21(3): 212-214, 2015.

2014

1. Tojo M, Nagamatsu M, Hayakawa K, Mezaki K, Kirikae T, Ohmagari N: Evaluation of an automated rapid diagnostic test for detection of Clostridium difficile. PLoS One. 9(8): e106102, 2014.
2. Taguchi T, Okada M, Kogai Y, Masuda M, Shimomura Y, Inoue M, Ito T, Hamahata T, Funatogawa K, Kirikae T, Furuzono T: Prevention of catheter infection using a biodegradable tissue adhesive composed of human serum albumin and disuccinimidyl tartrate. J Bioact Compat Pol. 29(3) 284-297, 2014.
3. Mori-Yoshikawa N, Ohmagari N, Kirikae T: Organization of nosocomial infection control measures and local networks for infectious disease control in middle-scale hospitals in Japan. Jpn J Infect Dis. 67: 379-381, 2014.
4. Tada T, Miyoshi-Akiyama T, Dahal RK, Mishra SK, Shimada K, Ohara H, Kirikae T, Pokhrel BM: Identification of a novel 6'-N-aminoglycoside acetyltransferase, AAC(6')-Iak, from a multidrug-resistant clinical isolate of Stenotrophomonas maltophilia. Antimicrob Agents Chemother .58(10): 6324-6327, 2014.
5. Tada T, Shrestha B, Miyoshi-Akiyama T, Shimada K, Ohara H, Kirikae T, Pokhrel BM: NDM-12, a novel New Delhi metallo-ß-lactamase variant from a carbapenem-resistant Escherichia coli clinical isolate in Nepal. Antimicrob Agents Chemother. 58(10): 6302-6305, 2014.
6. Tojo M, Tada T, Shimojima M, Tanaka M, Narahara K, Miyoshi-Akiyama T, Kirikae T, Ohmagari N: Dissemination in Japan of multidrug-resistant Pseudomonas aeruginosa isolates producing IMP-type metallo-ß-lactamases and AAC(6')-Iae/AAC(6')-Ib. J Infect Chemother 20: 586-588, 2014.
7. Hayakawa K, Miyoshi-Akiyama T, Kirikae T, Nagamatsu M, Shimada K, Mezaki K, Sugiki Y, Kuroda E, Kubota S, Takeshita N, Kutsuna S, Tojo M, Ohmagari N: Molecular and epidemiological characterization of IMP-type metallo-ß-lactamase-producing Enterobacter cloacae in a large tertiary care hospital in Japan. Antimicrob Agents Chemother 58(6): 3441-3450, 2014.
8. Tojo M, Fujita T, Ainoda Y, Nagamatsu M, Hayakawa K, Mezaki K, Sakurai A, Masui Y, Yazaki H, Takahashi H, Miyoshi-Akiyama T, Totsuka K, Kirikae T, Ohmagari N: Evaluation of an automated rapid diagnostic assay for detection of gram-negative bacteria and their drug-resistance genes in positive blood cultures. PLoS One. 9(4): e94064, 2014.
9. Tada T, Miyoshi-Akiyama T, Shimada K, Kirikae T: Biochemical analysis of metallo-ß-lactamase NDM-3 from a multidrug-resistant Escherichia coli strain isolated in Japan. Antimicrob Agents Chemother. 58(6): 3538-3540, 2014.
10. Uemura H, Hayakawa K, Shimada K, Tojo M, Nagamatsu M, Miyoshi-Akiyama T, Tamura S, Kazuhisa Mesaki K, Yamamoto K, Yanagawa Y, Sugihara J, Kutsuna S, Takeshita N, Shoda N, Hagiwara A, Kirikae T, Ohmagari N: Parvimonas micra as a causative organism of spondylodiscitis: a report of 2 cases and a literature review. Int J Infect Dis. 23:53-55, 2014.
11. Tada T, Miyoshi-Akiyama T, Shimada K, Shimojima M, Kirikae T: Dissemination of 16S rRNA methylase ArmA-producing Acinetobacter baumannii and emergence of OXA-72 carbapenemase coproducers in Japan. Antimicrob Agents Chemother. 58(5): 2916-2920, 2014.
12. Tada T, Miyoshi-Akiyama T, Dahal RK, Sah MK, Ohara H, Shimada K, Kirikae T, Pokhrel BM: NDM-1 Metallo-ß-Lactamase and ArmA 16S rRNA methylase producing Providencia rettgeri clinical isolates in Nepal. BMC Infect Dis. 14: 56 2014.
13. Ando H, Miyoshi-Akiyama T, Watanabe S, Kirikae T: A silent mutation of mabG1 confers isoniazid resistance on Mycobacterium tuberculosis. Mol Microbiol. 91(3): 538-547, 2014.
14. Hashimoto A, Nagamatsu M, Ohmagari N, Hayakawa K, Kato Y, Kirikae T: Isolation of OXA-48 carbapenemase-producing Klebsiella pneumoniae from a n overseas traveler returning to Japan. Jpn J Infect Dis. 67(2): 120-121, 2014.
15. Arai R, Miyoshi-Akiyama T, Okumura K, Morinaga Y, Meihua Wu, Sugimura Y, Yoshiyama M, Okura M, Kirikae T, Takamatsu D: Development of duplex PCR assay for detection and differentiation of typical and atypical Melissococcus plutonium strains. J Vet Med Sci. 76(4): 491-498, 2014.
16. Ichinose-Tsuno A, Aoki A, Takeuchi Y, Kirikae T, Shimbo T, Lee M, Yoshino F, Maruoka Y, Itoh T, Ishikawa I, Izumi Y.: Antimicrobial photodynamic therapy suppresses dental plaque formation in healthy adults: a randomized controlled clinical trial. BMC Oral Health. 14:152, 2014.

2013

1. Ohara-Imaizumi M, Kim H, Yoshida M, Fujiwara T, Aoyagi K, Toyofuku Y, Nakamichi Y, Nishiwaki C, Okamura T, Uchida T, Fujitani Y, Akagawa K, Kakei M, Watada H, German MS, Nagamatsu S: Serotonin regulates glucose-stimulated insulin secretion from pancreatic ß cells during pregnancy. Proc Nati Acad Sci USA. 110(48):19420-19425, 2013
2. Tada T, Miyoshi-Akiyama T, Dahal RK, Mishra SK, Ohara H, Shimada K, Kirikae T*, Pokhrel BM: Dissemination of multidrug-resistant Klebsiella pneumoniae clinical isolates with various combinations of carbapenemases (NDM-1 and OXA-72) and 16S rRNA methylases (ArmA, RmtC and RmtF) in Nepal. Int J Antimicrob Agents. 42(4):372-374, 2013.*corresponding author
3. Watanabe S, Kirikae T, Miyoshi-Akiyama T: Complete genome sequence of Streptococcus dysgalactiae subsp. equisimilis 167 carrying Lancefield group C antigen, and comparative genomics of S. dysgalactiae subsp. equisimilis strains. Genome Biol and Evol 5(9): 1644-1651, 2013.
4. Watanabe S, Shimomura Y, Ubukata K, Kirikae T, Miyoshi-Akiyama T: Concomitant regulations of host tissues-destructing virulence factors and carbohydrate metabolisms during invasive diseases in group G Streptococcus. J Infect Dis. 208(9):1482-1493, 2013.
5. Tada T, Miyoshi-Akiyama T, Shimada K, Shimojima M, Kirikae T: IMP-43 and IMP-44 metallo-ß-lactamases with increased carbapenemase activities in multidrug-resistant Pseudomonas aeruginosa. Antimicrob Agents Chemother. 57(9): 4427-4432, 2013.
6. Takamatsu D, Arai R, Miyoshi-Akiyama T, Okumura K, Okura M, Kirikae T, Kojima A, Osaki M: Identification of mutations involved in Potassium requirement for the growth of typical Melissococcus plutonius. Appl Environ Microbiol. 79(12):3882-3886, 2013.
7. Tada T, Miyoshi-Akiyama T, Shimada K, Shimojima M, Kirikae T: Novel 6'-N-Aminoglycoside Acetyltransferase, AAC(6')-Iaj, from a clinical isolate of Pseudomonas aeruginosa. Antimicrob Agents Chemother. 57(1): 96-100, 2013.
8. Hamada Y, Watanabe K, Tada T, Mezaki K, Takeuchi S, Shimizu T, Kirikae T, Ohmagari N: Erratum to: Three cases of IMP-type metallo-ß-lactamase-producing Enterobacter cloacae bloodstream infection in Japan. J Infect Chemother. 19(5)956-958, 2013.
9. Tada T, Miyoshi-Akiyama T, Kato Y, Ohmagari N, Takeshita N, Hung NV, Phuong DM, Thu TA, Binh NG, Anh NQ, Nga TTT, Truong PH, Xuan PT, Thu LeTA, Nguyen TS, Kirikae T: Emergence of 16S rRNA methylase- producing Acinetobacter baumannii and Pseudomonas aeruginosa isolates in hospitals in Vietnam. BMC Infectious Diseases 13(1):251, 2013
10. Miyoshi-Akiyama T, Hayakawa K, Ohmagari N, Shimojima M, Kirikae T: Multilocus sequence typing (MLST) for characterization of Enterobacter cloacae. PLoS One. 11:8(6) e66358, 2013
11. Tada T, Miyoshi-Akiyama T, Dahal RK, Sah MK, Ohara H, Kirikae T, Pokhrel BM: NDM-8 metallo-ß-lactamase in a multidrug-resistant Escherichia coli strain isolated in Nepal. Antimicrob Agents Chemother 57(5):2394- 2396, 2013.
12. Hashimoto M, Eguchi H, Tawaratsumida M, Kirikae T, Suda Y: Identification of a Toll-like receptor 2-stimulating lipoprotein in Bacteroides fragilis JCM 11019 (NCTC 9343). Innate Immun 19(2):132-139, 2013.
13. Wajima T, Sabui S, Kano S, Ramamurthy T, Chatterjee NS, Hamabata T: Entire sequence of the colonization factor coli surface antigen 6-encoding plasmid pCss165 from an enterotoxigenic Escherichia coli clinical isolate. Plasmid 70(3):343-52, 2013.
14. Sato T, Matsui T, Takita E, Kadoyama Y, Makino S, Kato K, Sawada K, Hamabata T.Evaluation of Recombinant Forms of the Shiga Toxin Variant Stx2eB Subunit and Non-Toxic Mutant Stx2e as Vaccine Candidates against Porcine Edema Disease. J Vet Med Sci. 1:75(10): 1309-1315. 2013.

2012

1. Fukushi M, Yamashita M, Miyoshi-Akiyama T, Kubo S, Yamamoto K, Kudo K.: Laninamivir octanoate and artificial surfactant combination therapy significantly increases survival of mice infected with lethal influenza H1N1 Virus. PLoS One. 7(8): e42419, 2012.
2. Miyoshi-Akiyama T, Takeshita N, Ohmagari N, Kirikae T: Complete genomesequence of Helicobacter cinaedi type strain ATCC BAA-847. J Bacteriol 194(20): 5692, 2012.
3. Miyoshi-Akiyama T, Watanabe S, Kirikae T: Complete genome sequence of Streptococcus pyogenes M1 476, isolated from a patient with streptococcal toxic shock syndrome. J Bacteriol 194: 5466, 2012.
4. Okumura K, Arai R, Okura M, Kirikae T, Takamatsu D, Osaki M, Miyoshi-Akiyama T: Complete genome sequence of Melissococcus plutonius DAT561, a strain that shows an unusual growth profile and is representative of an endemic cluster in Japan. J Bacteriol 194(11):3014, 2012.
5. Miyoshi-Akiyama T, Matsumura K, Iwai H, Funatogawa K, Kirikae T: Complete annotated genome sequence of Mycobacterium tuberculosis Erdman. J Bacteriol 194(10): 2770, 2012.
6. Fukushi M, Yoshinaka Y, Matsuoka Y, Hatakeyama S, Ishizaka Y, Kirikae T, Sasazuki T, Miyoshi-Akiyama T: Monitoring S protein maturation in the endoplasmic reticulum by calnexin is important for the infectivity of severe acute respiratory syndrome-coronavirus. J Virol 86(21): 11745-11753, 2012.
7. Kitao T, Tada T, Tanaka M, Narahara K, Shimojima M, Shimada K, Miyoshi-Akiyama T, Kirikae T: Emergence of a novel multidrug-resistant Pseudomonas aeruginosa strain producing IMP-type metallo-ß-lactamases and AAC(6')-Iae in Japan. Int J Antimicrob Agents 39(6): 518-521, 2012
8. Miyoshi-Akiyama T, Akasaka, Y, Oogane T, Kondo Y, Matsushita T, Funatogawa K, Kirikae T: Development and evaluation of a line probe assay for rapid typing of Influenza viruses and detection of the H274Y mutation. J Virol Method 185(2): 276-280, 2012.
9. Okumura K, Shimomura Y, Yamagata Murayama, S, Yagi J, Ubukata K, Kirikae T, Miyoshi-Akiyama T: Evolutionary path of streptococcal and staphylococcal superantigens. BMC Genomics 13(1): 404, 2012.
10. Niki M, Niki M, Tateishi Y, Ozeki Y, Kirikae T, Lewin A, Inoue Y, Matsumoto M, Dahl JL, Ogura H, Kobayashi K, Matsumoto S: A novel mechanism of growth phase-dependent tolerance to isoniazid in Mycobacteria. J Biol Chem. 287(33): 27743-27752, 2012.
11. 11. Tada T, Miyoshi-Akiyama T, Tanaka M, Narahara K, Shimojima M, Kitao T, Shimada K, Kirikae T: Development of an immunochromatographic assay for rapid detection of AAC(6')-Ib-producing Pseudomonas aeruginosa. J Microbiol Methods 91(1): 114-116, 2012.
12. Mitarai S, Kato S. Ogata H, Aono A, Chikamatsu K, Mizuno K, Toyota E, Sejimo A, Suzuki K, Yoshida S, Saito T, Moriya A, Fujita A, Sato S, Matsumoto T, Ano H, Suetake T, Kondo Y, Kirikae T*, Mori T: Comprehensive multicenter evaluation of a new line probe assay kit for identification of Mycobacterium species and detection of drug-resistant Mycobacterium tuberculosis. J Clin Microbiol 50(3): 884-890, 2012.*corresponding author
13. Ishizaka Y, Okudaira N, Tamura M, Iijima K, Shimura M, Goto M, Okamura T: Modes of retrotransposition of long interspersed element-1 by environmental factors. In Frontier in Virology. 191, 1-8, 2012.
14. *Okamura T Yanobu-Takanashi R, Takeuchi F, Isono M, Akiyama K, Shimizu Y, Goto M, Liang Y-Q, Yamamoto K, Katsuya T, Fujioka A, Ohnaka K, Takayanagi R, Ogihara T, Yamori Y, Kato N: Deletion of CDKAL1 Affects High-Fat Diet Induced Fat Accumulation and Glucose-Stimulated Insulin Secretion in Mice, Indicating Relevance to Diabetes. PLoS One. 7, e49055, 2012. *The authors equally contributed to this work.

2011

1. Ando H, Mitarai S, Kondo Y, Suetake T, Kato S, Mori T, Kirikae T: Evaluation of a line probe assay for rapid detection of gyrA mutations associated with fluoroquinolone resistance in multidrug-resistant Mycobacterium tuberculosis. J Med Microbiol 60(2): 184-188, 2011.
2. Shimomura Y, Okumura K, Murayama SY, Yagi J, Ubukata K, Kirikae T, Miyoshi-Akiyama T: Complete genome sequencing and analysis of a Lancefield group G Streptococcus dysgalactiae subsp. equisimilis strain causing streptococcal toxic shock syndrome (STSS). BMC Genomics 12: 17, 2011.
3. Hanaki K, Sekiguchi J, Shimada K, Sato A, Watari H, Kojima T, Miyoshi-Akiyama T, Kirikae T: Loop-mediated isothermal amplification assays for identification of antiseptic- and methicillin-resistant Staphylococcus aureus. J Microbiological Methods 84(2): 251-254, 2011.
4. Ando H, Kitao T, Miyoshi-Akiyama T, Kato S, Mori T, Kirikae T: Down-regulation of katG expression is associated with isoniazid resistance in Mycobacterium tuberculosis. Mol Microbiol 79(6):1615-1628, 2011.
5. Miyoshi-Akiyama T, Ishida I, Fukushi M, Yamaguchi K. Matsuoka Y, Ishihara T, Tsukahara M, Hatakeyama S, Itoh N, Morisawa A, Yoshinaka Y, Yamamoto N, Lianfeng Z, Chuan Q, Kirikae T, Sasazuki T: Fully human monoclonal antibody directed to proteolytic cleavage site in SARS coronavirus S protein neutralizes the virus in a rhesus macaque SARS model. J Infect Dis 203(11): 1574-1581, 2011.
6. Kawachi S, Matsushita T, Sato T, Nunoi H, Noguchi H, Ota S, Kanemoto N, Nakatani K, Nishiguchi T, Yuge A, Imamura H, Kitajima H, Narahara K, Suzuki K, Miyoshi-Akiyama T, Kirikae T: Multicenter prospective evaluation of a novel rapid immunochromatographic diagnostic kit specifically detecting influenza A H1N1 2009 virus. J Clin Viol 51(1): 68-72, 2011
7. Fukushi M, Ito T, Oka T, Kitazawa T, Miyoshi-Akiyama T, Kirikae T, Yamashita M, Kudo K: Serial histopathological examination of the lungs of mice infected with Influenza A virus PR8 strain. PLoS One 6(6):e21207. Epub 2011 Jun 20.
8. Okumura K, Arai R, Okura M, Kirikae T, Takamatsu D, Osaki M, Miyoshi-Akiyama T: Complete genome sequence of Melissococcus plutonius ATCC 35311. J Bacteriol 193(15): 4029-4030, 2011
9. Kitao T, Miyoshi-Akiyama T, Tanaka M, Narahara K, Shimojima M, Kirikae T: Development of an immunochromatographic assay for diagnosing the production of IMP-type metallo-ß-lactamases that mediate carbapenem resistance in Pseudomonas. J Microbiol Methods 87(3): 330-337, 2011.
10. Tada T, Kitao T, Miyoshi-Akiyama T, Kirikae T: Genome sequence of multidrug-resistant Pseudomonas aeruginosa NCGM1179. J Bacteriol 193(22): 6397, 2011.
11. Miyoshi-Akiyama T, Matsumura K, Kobayashi N, Maeda S, Kirikae T: Genome sequence of clinical isolate Mycobacterium tuberculosis NCGM2209. J Bacteriol 193(23): 6792, 2011.
12. Miyoshi-Akiyama T, Kuwahara T, Tada T, Kitao T, Kirikae T: Complete genome sequence of highly multidrug- resistant Pseudomonas aeruginosa NCGM2.S1, a representative strain of a cluster endemic to Japan. J Bacteriol 193(24): 7010, 2011.
13. Wajima T, Sabui S, Fukumoto M, Kano S, Ramamurthy T, Chatterjee NS, Hamabata T: Enterotoxigenic Escherichia coli CS6 gene products and their role in CS6 structural protein assembly and cellular adherence. Microb Pathog 51: 243-249, 2011.
14. Okudaira N, Goto M, Yanobu-Takanashi R, Tamura M, An A, Abe Y, Kano S, Hagiwara S, Ishizaka Y, Okamura T: Involvement of retrotransposition of long interspersed nucleotide element-1 in skin tumorigenesis induced by 7,12- dimethylbenz[a]anthracene and 12-O-tetradecanoylphorbol-13-acetate. Cancer Sci. 102, 2000-2006, 2011.
15. Sasawatari S, *Okamura T, *Kasumi E, Tanaka-Furuyama K, Yanobu-Takanashi, R, Shirasawa S, Kato N, Toyama-Sorimachi N.* The solute carrier family15A4 regulates TLR9 and NOD1 functions in the innate immune system and promotes colitis in mice. *These authors equally contributed to this work. Gastroenterology, 140, 1513- 1525, 2011.

2010

1. Ando H, Mitarai S, Kondo Y, Suetake T, Sekiguchi J, Kato S, Mori T, Kirikae T: Pyrazinamide resistance in multidrug-resistant Mycobacterium tuberculosis isolates in Japan. Clin Microbiol Infect 54: 1793-1799, 2010.
2. Ando H, Kondo Y, Suetake T, Toyota E, Kato S, Mori, T, Kirikae T: Identification of katG mutations associated with high-level isoniazid resistance in Mycobacterium tuberculosis. Antimicrob. Agents Chemother 54(5): 1793- 1799, 2010.
3. Goto M, Shimada K, Sato A, Takahashi E, Fukasawa T, Takahashi T, Ohka S, Taniguchi T, Honda E, Nomoto A, Ogura A, Kirikae T, Hanaki K: Rapid detection of Pseudomonas aeruginosa in mouse feces by colorimetric loop- mediated isothermal amplification. J Microbiol Methods 81: 247-252. 2010.
4. Kitao T, Miyoshi-Akiyama T, Shimada K, Tanaka M, Narahara K, Saito N, Kirikae T: Development of an immunochromatographic assay for the rapid detection of AAC(6')-Iae-producing multidrug-resistant Pseudomonas aeruginosa. J Antimicrob Chemother 65: 1382-1386, 2010.
5. Miyoshi-Akiyama T, Narahara K, Mori S, Kitajima H, Kase T, Morikawa S, Kirikae T: Development of an immunochromatographic assay specifically detecting pandemic H1N1 (2009) influenza virus. J Clin. Microbiol 48(3): 703-708, 2010.

2009

1. Miyoshi-Akiyama T, Zhao J, Uchiyama T, Yagi J, Kirikae T: Positive correlation between low adhesion of group A Streptococcus to mammalian cells and virulence in a mouse model. FEMS Microbiol Lett 293:107-114, 2009.
2. Kitao T, Miyoshi-Akiyama T, Kirikae T: AAC(6')-Iaf, a novel aminoglycoside 6'-N-acetyltransferase from multidrug-resistant Pseudomonas aeruginosa clinical isolates. Antimicrob. Agents Chemother 6:2327-2334, 2009.
3. Patrick MS, Oda H, Hayakawa K, Sato Y, Eshima K, Kirikae T, Iemura S, Shirai M, Abe T. Natsume T, Sasazuki T, Suzuki H: Gasp, a Grb2-associating protein, is critical for positive selection of thymocytes. Proc Natl Acad Sci USA 106: 16345-16350. 2009.

2008

1. Xu H, Sullivan TJ, Sekiguchi J, Kirikae T, Ojima I, Stratton CF, Mao W, Rock FL, Alley MR, Johnson F, Walker SG, Tonge PJ.: Mechanism and inhibition of saFabI, the enoyl reductase from Staphylococcus aureus. Biochemistry 47(14): 4228-4236, 2008.
2. Kanoh K, Adachi K, Matsuda S, Shizuri Y, Yasumoto K, Kusumi T, Okumura K, Kirikae T: New Sulfoalkylresorcinol from Marine-derived Fungus, Zygosporium sp. KNC52. J Antibiotics 61 (3): 192-194, 2008.
3. Nishiyama A, Wakasugi N, Kirikae T, Quy T, Ha le D, Ban VV, Long HT, Keicho N, Sasazuki T, Kuratsuji T: Risk factors for SARS infection within hospitals in Hanoi, Vietnam. Jpn J Infect Dis 61(5): 388-390, 2008.
4. Hatakeyama S, Matsuoka Y, Ueshiba H, Komatsu N, Itoh K, Shichijo S, Kanai T, Fukushi M, Ishida I, Kirikae T, Sasazuki T, Miyoshi-Akiyama T.: Dissection and identification of regions required to form pseudoparticles by the interaction between the nucleocapsid (N) and membrane (M) proteins of SARS coronavirus. Virology 380(1): 99-108, 2008.
5. Sekiguchi J, Morita K, Kitao T, Watanabe N, Okazaki M, Miyoshi-Akiyama T, Kanamori M, Kirikae T.: KHM-1, a novel plasmid-mediated metallo-ß-lactamase from a Citrobacter freundii clinical isolate. Antimicrob Agents Chemother 52(11): 4194-4197, 2008.