2016年（平成28年）

原著論文－英文

1. Spracklen CN, Chen P, Kim YJ, Wang X, Cai H, Li S, Long J, Wu Y, Wang YX, Takeuchi F, Wu JY, Jung KJ, Hu C, Akiyama K, Zhang Y, Moon S, Johnson TA, Li H, Dorajoo R, He M, Cannon ME, Roman TS, Salfati E, Lin KH, Guo X, Sheu WH, Absher D, Adair LS, Assimes TL, Aung T, Cai Q, Chang LC, Chen CH, Chien LH, Chuang LM, Chuang SC, Du S, Fan Q, Fann CS, Feranil AB, Friedlander Y, Gordon-Larsen P, Gu D, Gui L, Guo Z, Heng CK, Hixson J, Hou X, Hsiung CA, Hu Y, Hwang MY, Hwu CM, Isono M, Juang JJ, Khor CC, Kim YK, Koh WP, Kubo M, Lee IT, Lee SJ, Lee WJ, Liang KW, Lim B, Lim SH, Liu J, Nabika T, Pan WH, Peng H, Quertermous T, Sabanayagam C, Sandow K, Shi J, Sun L, Tan PC, Tan SP, Taylor KD, Teo YY, Toh SA, Tsunoda T, van Dam RM, Wang A, Wang F, Wang J, Wei WB, Xiang YB, Yao J, Yuan JM, Zhang R, Zhao W, Chen YI, Rich SS, Rotter JI, Wang TD, Wu T, Lin X, Han BG, Tanaka T, Cho YS, Katsuya T, Jia W, Jee SH, Chen YT, Kato N, Jonas JB, Cheng CY, Shu XO, He J, Zheng W, Wong TY, Huang W, Kim BJ, Tai ES, Mohlke KL, Sim X.
   Association analyses of East Asian individuals and trans-ancestry analyses with European individuals reveal new loci associated with cholesterol and triglyceride levels.
   Hum Mol Genet. Feb 21, 2017. [Epub ahead of print]
2. Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I, Surendran P, Liu C, Cook JP, Kraja AT, Drenos F, Loh M, Verweij N, Marten J, Karaman I, Lepe MP, O'Reilly PF, Knight J, Snieder H, Kato N, He J, Tai ES, Said MA, Porteous D, Alver M, Poulter N, Farrall M, Gansevoort RT, Padmanabhan S, Mägi R, Stanton A, Connell J, Bakker SJ, Metspalu A, Shields DC, Thom S, Brown M, Sever P, Esko T, Hayward C, van der Harst P, Saleheen D, Chowdhury R, Chambers JC, Chasman DI, Chakravarti A, Newton-Cheh C, Lindgren CM, Levy D, Kooner JS, Keavney B, Tomaszewski M, Samani NJ, Howson JM, Tobin MD, Munroe PB, Ehret GB, Wain LV; International Consortium of Blood Pressure (ICBP) 1000G Analyses; BIOS Consortium; Lifelines Cohort Study; Understanding Society Scientific group; CHD Exome+ Consortium; ExomeBP Consortium; T2D-GENES Consortium; GoT2DGenes Consortium; Cohorts for Heart and Ageing Research in Genome Epidemiology (CHARGE) BP Exome Consortium; International Genomics of Blood Pressure (iGEN-BP) Consortium, Barnes MR, Tzoulaki I, Caulfield MJ, Elliott P; UK Biobank CardioMetabolic Consortium BP working group.
   Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.
   Nat Genet. 49(3):403-415, Jan 30, 2017. doi: 10.1038/ng.3768. [Epub ahead of print]
3. Liu X, Lu D, Saw WY, Shaw PJ, Wangkumhang P, Ngamphiw C, Fucharoen S, Lert-Itthiporn W, Chin-Inmanu K, Chau TN, Anders K, Kasturiratne A, de Silva HJ, Katsuya T, Kimura R, Nabika T, Ohkubo T, Tabara Y, Takeuchi F, Yamamoto K, Yokota M, Mamatyusupu D, Yang W, Chung YJ, Jin L, Hoh BP, Wickremasinghe AR, Ong RH, Khor CC, Dunstan SJ, Simmons C, Tongsima S, Suriyaphol P, Kato N, Xu S, Teo YY.
   Characterising private and shared signatures of positive selection in 37 Asian populations.
   Eur J Hum Genet. 25(4):499-508, Apr, 2017.
4. Wahl S, Drong A, Lehne B, Loh M, Scott WR, Kunze S, Tsai PC, Ried JS, Zhang W, Yang Y, Tan S, Fiorito G, Franke L, Guarrera S, Kasela S, Kriebel J, Richmond RC, Adamo M, Afzal U, Ala-Korpela M, Albetti B, Ammerpohl O, Apperley JF, Beekman M, Bertazzi PA, Black SL, Blancher C, Bonder MJ, Brosch M, Carstensen-Kirberg M, de Craen AJ, de Lusignan S, Dehghan A, Elkalaawy M, Fischer K, Franco OH, Gaunt TR, Hampe J, Hashemi M, Isaacs A, Jenkinson A, Jha S, Kato N, Krogh V, Laffan M, Meisinger C, Meitinger T, Mok ZY, Motta V, Ng HK, Nikolakopoulou Z, Nteliopoulos G, Panico S, Pervjakova N, Prokisch H, Rathmann W, Roden M, Rota F, Rozario MA, Sandling JK, Schafmayer C, Schramm K, Siebert R, Slagboom PE, Soininen P, Stolk L, Strauch K, Tai ES, Tarantini L, Thorand B, Tigchelaar EF, Tumino R, Uitterlinden AG, van Duijn C, van Meurs JB, Vineis P, Wickremasinghe AR, Wijmenga C, Yang TP, Yuan W, Zhernakova A, Batterham RL, Smith GD, Deloukas P, Heijmans BT, Herder C, Hofman A, Lindgren CM, Milani L, van der Harst P, Peters A, Illig T, Relton CL, Waldenberger M, Järvelin MR, Bollati V, Soong R, Spector TD, Scott J, McCarthy MI, Elliott P, Bell JT, Matullo G, Gieger C, Kooner JS, Grallert H, Chambers JC.
   Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity.
   Nature. 541(7635):81-86, Jan 5, 2017. doi: 10.1038/nature20784.
5. Gregson JM, Freitag DF, Surendran P, Stitziel NO, Chowdhury R, Burgess S, Kaptoge S, Gao P, Staley JR, Willeit P, Nielsen SF, Caslake M, Trompet S, Polfus LM, Kuulasmaa K, Kontto J, Perola M, Blankenberg S, Veronesi G, Gianfagna F, Männistö S, Kimura A, Lin H, Reilly DF, Gorski M, Mijatovic V; CKDGen consortium., Munroe PB, Ehret GB; International Consortium for Blood Pressure., Thompson A, Uria-Nickelsen M, Malarstig A, Dehghan A; CHARGE inflammation working group., Vogt TF, Sasaoka T, Takeuchi F, Kato N, Yamada Y, Kee F, Müller-Nurasyid M, Ferrières J, Arveiler D, Amouyel P, Salomaa V, Boerwinkle E, Thompson SG, Ford I, Wouter Jukema J, Sattar N, Packard CJ, Shafi Majumder AA, Alam DS, Deloukas P, Schunkert H, Samani NJ, Kathiresan S; MICAD Exome consortium., Nordestgaard BG, Saleheen D, Howson JM, Di Angelantonio E, Butterworth AS, Danesh J; EPIC-CVD consortium and the CHD Exome+ consortium.
   Genetic invalidation of Lp-PLA2 as a therapeutic target: Large-scale study of five functional Lp-PLA2-lowering alleles.
   Eur J Prev Cardiol. 24(5):492-504, Mar, 2017.
6. Kawamura R, Tabara Y, Tsukada A, Igase M, Ohashi J, Yamada R, Takata Y, Kawamoto R, Saito I, Onuma H, Tanigawa T, Yamada K, Kato N, Ohyagi Y, Miki T, Kohara K, Osawa H.
   A genome-wide association study of plasma resistin levels identified rs1423096 and rs10401670 as possible functional variants in the Japanese population.
   Physiol Genomics. Sep 23, 2016. [Epub ahead of print]
7. Sugiyama K, Sasano T, Kurokawa J, Takahashi K, Okamura T, Kato N, Isobe M, Furukawa T.
   Oxidative Stress Induced Ventricular Arrhythmia and Impairment of Cardiac Function in Nos1ap Deleted Mice.
   Int Heart J. 57(3):341-9, May 25, 2016.

原著論文－和文

口頭・ポスター発表－国際学会・研究会

1. Spracklen CN, Kim Y.J, Chen P, Sim X, Cai H, Li S, Long J, Wu Y, Wang X, Wang YX, Takeuchi F, Jung KJ, Wu JY, Johnson T.A, Li H, Dorajoo R, He M, Akiyama K, Zhang Y, Hou X, Hu C, Moon S, Salfati E, AGEN Consortium.
   Association analyses of up to 72,043 East Asian individuals and trans-ancestry analyses with up to 186,265 European individuals reveal new loci associated with cholesterol and triglyceride levels.
   61st annual meeting of the American Society of Human Genetics. Vancouver, Canada, Oct, 2016.
2. Niriella MA, De Silva ST, Kasturiratna A, Perera KR, Subasinghe SKCE, Kodisinghe SK, Piyaratna TACL, Vithiya K, Dassanayaka AS, De Silva AP, Pathmeswaran A, Wickramasinghe AR, Kato N, de Silva HJ.
   Lean non-alcoholic fatty liver disease (Lean-NAFLD): characteristics and risk factors from a community cohort follow up study.
   UEG week 2016. Vienna, Austria, Oct 2016.
3. Kato N.
   DNA methylation and hypertension.
   Cardiovascular Genetics, Satellite Symposium of ISH 2016. Tokyo, Japan, Sep, 2016.
4. Shimizu-Furusawa H, Takeuchi F, Isono M, Akiyama K, Liang Y-Q, Kato N.
   Epigenetic changes in the brain with high-salt intervention in SHR.
   Cardiovascular Genetics, Satellite Symposium of ISH 2016. Tokyo, Japan, Sep, 2016.
5. Shimizu-Furusawa H, Takeuchi F, Isono M, Akiyama K, Liang Y-Q, Kato N.
   Epigenetic changes in the liver with high-fat-diet intervention in SHR.
   Cardiovascular Genetics, Satellite Symposium of ISH 2016. Tokyo, Japan, Sep, 2016.
6. Shimizu-Furusawa H, Takeuchi F, Isono M, Akiyama K, Liang Y-Q, Kato N.
   Epigenetic changes in the liver with dexamethasone administration in SHR.
   Cardiovascular Genetics, Satellite Symposium of ISH 2016. Tokyo, Japan, Sep, 2016.
7. Shimizu-Furusawa H, Takeuchi F, Isono M, Akiyama K, Liang Y-Q, Kato N.
   Comparison of epigenetic changes in the liver between Tg-CETP rat and SHR.
   Cardiovascular Genetics, Satellite Symposium of ISH 2016. Tokyo, Japan, Sep, 2016.
8. Shimizu-Furusawa H, Takeuchi F, Isono M, Akiyama K, Liang Y-Q, Kato N.
   Comparison of epigenetic changes in the liver between RNO4-derived congenic rat and progenitor strains.
   Cardiovascular Genetics, Satellite Symposium of ISH 2016. Tokyo, Japan, Sep, 2016.
9. Konoshita T, Sakai A, Kaeriyama S, Urabe M, Nakaya T, Yamada M, Ichikawa M, Sato S, Yamamoto K, Imagawa M, Fujii M, Zenimaru Y, Suzuki J, Makino Y, Ishizuka T, Kato N.
   Association study of angiotensinase A (ENPEP) genotype with diabetic nephropathy.
   26th European Meeting on Hypertension and Cardiovascular Protection. Paris, France, Jun, 2016.
10. Kato N.
    Genomic medicine in NCDs: findings from Asians/ South Asians to global collaboration.
    25th Anniversary International Scientific Conference University of Kelaniya. Ragama, Sri Lanka, Apr, 2016.

口頭・ポスター発表－国内学会・研究会

1. 加藤 規弘.
   ゲノム医療の国際連携と我が国の取り組み.
   日本遺伝子診療学会：遺伝子診断・検査技術推進フォーラム. 公開シンポジウム2016, 東京, 12月, 2016.
2. 加藤 規弘.
   国内外のバイオバンクの動向やNCBNの取組みについて.
   第22回日本薬剤疫学会. 京都, 11月, 2016.
3. 島貫 秀之, 池田 仁子, 西本 寛, 若尾 文彦, 平松 治彦, 大塚 文之, 東山 綾, 高田 彰, 永井 秀明, 波多野 賢二, 松村 亮, 菊池 嘉, 秋山 純一, 廣井 透雄, 美代 賢吾, 野口 貴史, 渡辺 浩, 武田 美江, 岩田 悟, 峯 有佳, 渡邉 裕司, 三上 礼子, 加藤 規弘.
   ナショナルセンター・バイオバンクネットワークのカタログデータベースの現状とこれから.
   第36回医療情報学連合大会. 横浜, 11月, 2016.
4. 竹内 史比古, 清水 華, 加藤 規弘.
   ゲノムワイド関連解析とエピゲノム解析による高血圧の機序解明.
   第39回日本高血圧学会総会. 仙台, 10月, 2016.
5. 清水 華, 竹内 史比古, 磯野 正人, 秋山 康一, 梁 一強, 加藤 規弘.
   高血圧自然発症ラットの脳における, 食塩負荷に伴うエピジェネティック変化.
   第39回日本高血圧学会総会. 仙台, 10月, 2016.
6. 清水 華, 竹内 史比古, 磯野 正人, 秋山 康一, 梁 一強, 加藤 規弘.
   高血圧自然発症ラットの肝臓における, デキサメタゾン投与に伴うエピジェネティック変化.
   第39回日本高血圧学会総会. 仙台, 10月, 2016.
7. 加藤 規弘.
   高血圧および関連疾患のゲノム研究.
   第39回日本高血圧学会総会. 仙台, 10月, 2016.
8. 加藤 規弘.
   高血圧等の生活習慣病のゲノム／エピゲノム解析.
   第4回低酸素研究会. 東京, 7月, 2016.
9. 大澤 春彦, 田原 康玄, 川村 良一, 塚田 晃子, 伊賀瀬 道也, 大橋 順, 山田 亮, 高田 康徳, 川本 龍一, 斉藤 功, 大沼 裕, 小原 克彦, 谷川 武, 大八木 保政, 山田一哉, 加藤 規弘, 三木 哲郎.
   レジスチン遺伝子プロモーターSNPとは独立して、新たな機能的SNPとして3’のrs1423096とrs10401670を同定した.
   第59回日本糖尿病学会年次学術集会. 京都. 5月. 2016.

著書・総説

その他