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Molecular Diabetic Medicine
Research Topic
In type 2 diabetes, insulin resistance in insulin target organs (adipose tissue, muscle, liver, etc.) leads to failure of compensatory insulin secretion in pancreatic beta cells. Our research group focuses on insulin target organs and pancreatic beta cells involved in the pathogenesis of type 2 diabetes, using genetically engineered mouse models and clinical specimens to analyze the mechanisms of glucose metabolism homeostasis and its disruption in individuals at the molecular level. The goal is to propose new therapeutic strategies for type 2 diabetes.
Major research projects include
- Elucidation of the pathogenic mechanisms of obesity-induced insulin resistance and diabetes
- Elucidation of the role of insulin action in the development of aging-related diseases
- Elucidation of the maintenance mechanism of pancreatic beta cells and development of treatment for type 2 diabetes by restoring pancreatic beta cells
- Elucidation of the mechanism of hepatocarcinogenesis in diabetes-associated MASH
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Main Staff
| Director | Kohjiro Ueki |
|---|---|
| Chief, Section of Integrative Physiology | Motoharu Awazawa |
| Senior Research Fellow | Naoki Kobayashi Kotaro Soeda |
| Research Fellows | Hiroaki Tsuruta Mai Yoshida |
| Visiting Research Fellows | Takayoshi Sasako Yoshiko Ikushima-Matsumoto Maya Matsushita |
| Technical Assistant | Fumiya Takahashi Ikumi Nomura |
| Research student | Ye Yangli |
