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Molecular Metabolic Regulation
Research Topic
The aim of our research is to elucidate the molecular etiology and pathogenesis of obesity-related metabolic diseases, such as type 2 diabetes and non-alcoholic fatty liver diseases (NAFLD), and metabolic carcinogenesis using animal and cellular models, and to establish new therapeutic strategies through the identification of drug targets. Our current research interests are listed below.
- Molecular mechanisms of hormone-mediated metabolic regulation in particular, gene transcription-mediated metabolic regulation and dysregulation
- Research on inter-organ crosstalk in the development of insulin resistance
- Identification of novel molecules involved in the regulation of energy metabolism
- Elucidation of the pathogenesis of NAFLD and NAFLD-related hepatocarcinogenesis
- Elucidation of the pathophysiology and treatment of atherosclerosis as a complication of diabetes mellitus, focusing on the elucidation of molecular mechanisms of hepatic dyslipidemia induced by insulin resistance
- Research on the epigenetic regulation of metabolism in response to hormones
Main Staff
| Director | Michihiro Matsumoto |
|---|---|
| Division Chief, Division of Molecular and Cellular Metabolism | Michihiro Matsumoto |
| Senior Research Fellows | Masaru Mitsushima Takao Naganuma |
| Research Fellows | Toshiya Matsukawa |
| Research Students | Hiroyuki Yano |
| Research Assistants | Karin Endo Hiroko Kobayashi |
