トップページ > 研究部紹介 > 脂質シグナリングプロジェクト > 業績 > 2014年度発表論文等一覧

原著論文－英文

  1. Sumida H, Yanagida K, Kita Y, Abe J, Matsushima K, Nakamura M, Ishii S, Sato S, Shimizu T.
    Interplay between CXCR2 and BLT1 facilitates neutrophil infiltration and resultant keratinocyte activation in a murine model of imiquimod-induced psoriasis.
    J. Immunol. 192.4361-4369, 2014.
  2. Liu M, Saeki K, Matsunobu T, Okuno T, Koga T, Sugimoto Y, Yokoyama C, Nakamizo S, Kabashima K, Narumiya S, Shimizu T, Yokomizo T.
    12-Hydroxyhpetadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via BLT2 receptor.
    J. Exp. Med. 211.1063-78, 2014.
  3. Morimoto R, Shindou H, Tarui M, Shimizu T.
    Rapid Production of Platelet-activating Factor Is Induced by Protein Kinase Cα-mediated Phosphorylation of Lysophosphatidylcholine Acyltransferase 2 Protein.
    J. Biol. Chem. 289. 15566-15576, 2014.
  4. Harayama T, Eto M, Shindou H, Kita Y, Otsubo E, Hishikawa D, Ishii S, Sakimura K, Mishina M, Shimizu T.
    Lysophospholipid acyltransferases mediate phosphatidylcholine diversification to achieve the physical properties required in vivo. Cell metab. 20. 295-305, 2014.
  5. Tarui M, Shindou H, Kumagai K, Morimoto R, Harayama T, Hashidate T, Kojima H, Okabe T, Nagano T, Nagase T, Shimizu T.
    Selective inhibitors of a PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2.
    J. Lipid Res. 55. 1386-1396, 2014.
  6. Yoshioka W, Kawaguchi T, Fujisawa N, Aida-Yasuoka K, Shimizu T, Matsumura F, Tohyama C.
    Predominant role of cytosolic phospholipase A2alpha in dioxin-induced neonatal hydronephrosis in mice.
    Sci. Rep. 4, 4042, 2014.
  7. Koeberle A, Pergola C, Shindou H, Koeberle SC, Shimizu T, Laufer SA, Werz O.
    Role of p38 mitogen-activated protein kinase in linking stearoyl-CoA desaturase-1 activity with ER homeostasis.
    FASEB J. 29. 2439-2449, 2015.
  8. Yasuda D, Imura Y, Ishii S, Shimizu T, Nakamura M.
    The atypical N-glycosylation motif, Asn-Cys-Cys, in human GPR109A is required for normal cell surface expression and
    intracellular signaling.
    FASEB J. 29. 2412-22, 2015.
  9. Yamaguchi M, Matsui M, Higa R, Yamazaki Y, Ikari A, Miyake M, Miwa M, Ishii S, Sugatani J, Shimizu T.
    A platelet-activating factor (PAF) receptor deficiency exacerbates dietinduced obesity but PAF/PAF receptor signaling does not contribute to the development of obestiy-induced chronic inflammation. Biochem.
    Pharmacol. 93, 482-495, 2015.

原著論文－和文

口頭・ポスター発表－国際学会・研究会

  1. 山田 真希, 北 芳博, 徳岡 涼美, 小平 貴博, 清水 孝雄.
    A comprehensive monitoring method for lipid mediators using a high-speed LC/MS with continuous ionization polarity switching
    62nd ASMS Conference. Baltimore, USA, Jun 15-19, 2014.
  2. 山田 真希, 北 芳博, 小平 貴博, 徳岡 涼美, 清水 孝雄.
    Development and evaluation of a comprehensive monitoring method for eicosanoid species using a high-speed LC/MS with continuous ionization polarity switching.
    Metabolomics 2014. 鶴岡, 山形, Jun 23-26, 2014.
  3. Takao Shimizu.
    Sec14L3, a novel protein recognizing liposome curvature and packing defects.
    LIPID MAPS Annual Meeting 2014 Lipidomics Impact on Cell Biology, Inflammation and Metabolic Disease. Scripps Seaside Forum of the University of California San Diego's Scripps Institution of Oceanography, 8610 Kennel Way (formerly Discovery Way), La Jolla, CA 92037, May 13-14, 2014.
  4. Kenji Yoshida, Yoshihiro Kita, Suzumi Tokuoka, Kenji Sakimura, Masanobu Kano, Takao Shimizu.
    Deficiency of monoacylglycerol lipase attenuates diet-induced obesity in an endocannabinoid system-independent manner.
    LIPID MAPS Annual Meeting 2014 Lipidomics Impact on Cell Biology, Inflammation and Metabolic Disease. Scripps Seaside Forum of the University of California San Diego's Scripps Institution of Oceanography, 8610 Kennel Way (formerly Discovery Way), La Jolla, CA 92037, May 13-14, 2014.
  5. Yoshihiro Kita, Kenji Yoshida, Suzumi M. Tokuoka, Fumie Hamano, Kenji Sakimura, Masanobu Kano, Takao Shimizu. Monoacylglycerol lipase mediates fever via hypothalamic prostaglandin E2 production.
    LIPID MAPS Annual Meeting 2014 Lipidomics Impact on Cell Biology, Inflammation and Metabolic Disease. Scripps Seaside Forum of the University of California San Diego's Scripps Institution of Oceanography, 8610 Kennel Way (formerly Discovery Way), La Jolla, CA 92037, May 13-14, 2014.
  6. Suzumi Tokuoka, Yoshihiro Kita, Masaki Yamada, Takao Shimizu.
    Development of glycerophospholipid profiling methods using ternary gradient liquid chromatography/ high-speed triple quadrupole mass spectrometry.
    LIPID MAPS Annual Meeting 2014 Lipidomics Impact on Cell Biology, Inflammation and Metabolic Disease. Scripps Seaside Forum of the University of California San Diego's Scripps Institution of Oceanography, 8610 Kennel Way (formerly Discovery Way), La Jolla, CA 92037, May 13-14, 2014.
  7. Hideo Shindou, Ryo Morimoto, Megumi Tarui, Takao Shimizu.
    Rapid phosphorylation and activation of lysophosphatidylcholine acyltransferase 2 via protein kinase c.
    FASEB Phospholipid Cell Signaling and Metabolism in Inflammation and Cancer. Sheraton At The Falls, 300 3rd Street Niagara Falls, NY14303, Jun 1-6, 2014.
  8. Takao Shimizu.
    Regulation of membrane phospholipids in health and disease.
    55th International Conference on the Bioscience of Lipids: Lipids as Mediators of Health and Disease, University of Aberdeen, Aberdeen AB24 3FX Scotland, Jun 23-27, 2014.
  9. Miki Eto, Hideo Shindou, Takao Shimizu. Identification of a novel lysophosphatidic acid acyltransferase enzyme (LPAAT4) with preference for polyunsaturated fatty acyl-CoA.
    55th International Conference on the Bioscience of Lipids: Lipids as Mediators of Health and Disease, University of Aberdeen, Aberdeen AB24 3FX Scotland, Jun 23-27, 2014.
  10. Ryo Morimoto, Hideo Shindou, Megumi Tarui, Takao Shimizu.
    Phosphorylated lysophosphatidylcholine acyltransferase 2 (LPCAT2) mediates rapid platelet-activating factor (PAF) production following PAF- or ATP-stimulation in macrophages.
    55th International Conference on the Bioscience of Lipids: Lipids as Mediators of Health and Disease, University of Aberdeen, Aberdeen AB24 3FX Scotland, Jun 23-27, 2014.
  11. Daisuke Hishikawa, Hideo Shindou, Takeshi Harayama, Rie Ogasawara, Akira Suwabe, Takao Shimizu.
    Identification of novel pulmonary surfactant lipid-related protein, Sec14-like 3. FASEB The Lung Epithelium in Health and Disease Vermont Academy, Saxtons River, Vermont, USA, Jul 27-Aug 1, 2014.
  12. Takao Shimizu.
    Characterization of lysophospholipid and acyltransferase in vitro and vivo.
    Lipid Mediators in Health and Disease in Kalolinska Institute. Sweeden Kalolinska Institute, Stockholm, Sweden, Aug 27, 2014.
  13. Hideo Shindou, Takao Shimizu.
    Membrane remodeling by lysophospholipid acyltransferases Conferences Jacques Monod.
    Roscoff (Brittany), France, Nov 15-19, 2014.
  14. Miki Eto, Hideo Shindou, Takao Shimizu.
    Identification of lysophosphatidic acid acyltransferase 4 (LPAAT4), a possible role for incorporating DHA into glycerophospholipids.
    Max Planck-The University of Tokyo Center Symposium 2014. Harnack House. The Conference Venue of the Max Planck Society Ihnestr. 16-20 - 14195, Berlin, Dec 17, 2014.
  15. Ryo Morimoto.
    Calcium signaling triggers platelet-activating factor (PAF) biosynthesis.
    Max Planck-The University of Tokyo Center Symposium 2014. Harnack House. The Conference Venue of the Max Planck Society Ihnestr. 16-20 - 14195, Berlin, Dec 17, 2014.
  16. 清水 孝雄.
    LPA（lysophosphatidic acid） acts on non-Edg type receptors
    10th 都医学研国際シンポジウム, Tokyo, Feb 9, 2015.
  17. 清水 孝雄.
    Diversity of membrane phospholipids: biosynthetic mechanism and biological significance.
    6th International Conference on Phospholipase A2 and Lipid Mediators PLM2015. Tokyo, Feb 10-12, 2015.
  18. 吉田 憲司, 北 芳博, 徳岡 涼美, 崎村 建司, 狩野 方伸, 清水 孝雄.
    Monoacylglycerol lipase knockout mice are resistant to high fat diet-induced obesity in an endocannabinoid system-independent
    manner.
    6th International Conference on Phospholipase A2 and Lipid Mediators PLM2015. Tokyo, Feb 10-12, 2015.
  19. Miki Eto, Hideo Shindou, Takao Shimizu.
    Lysophosphatidic acid acyltransferase 4 (LPAAT4), a novel enzyme with activity for incorporating DHA into glycerophospholipids.
    6th International Conference on Phospholipase A2 and Lipid Mediators PLM2015. Tokyo, Feb 10-12, 2015.
  20. 北 芳博, 吉田 憲司, 徳岡 涼美, 浜野 文三江, 崎村 建司, 狩野 方伸, 清水 孝雄.
    Roles for monoacylglycerol lipase in inflammation and metabolic syndrome.
    6th International Conference on Phospholipase A2 and Lipid Mediators PLM2015. Tokyo, Feb 10-12, 2015.
  21. 徳岡 涼美, 北 芳博, 山田 真希, 清水 孝雄.
    Development of glycerophospholipid profiling method for biological samples using ternary gradient liquid chromatography/selected reaction monitoring mass.
    6th International Conference on Phospholipase A2 and Lipid Mediators PLM2015. Tokyo, Feb 10-12, 2015.

口頭・ポスター発表－国内学会・研究会

  1. 衛藤 樹, 進藤 英雄, 清水 孝雄.
    多価不飽和脂肪酸含有リン脂質合成に関わる新規リゾホスファチジン酸アシル転移酵素(LPAAT4)の同定.
    第56回日本脂質生化学会. 近畿大学 東大阪キャンパス, 東大阪, 6月, 2014.
  2. 吉田 憲司, 北 芳博, 徳岡 涼美, 崎村 建司, 狩野 方伸, 清水 孝雄.
    モノアシルグリセロールリパーゼ欠損は高脂肪食負荷による肥満を抑制する.
    第56回日本脂質生化学会. 近畿大学 東大阪キャンパス, 東大阪, 6月, 2014.
  3. 森本 亮, 進藤 英雄, 垂井 愛, 清水 孝雄.
    PKCαを介した血小板活性化因子合成酵素LPCAT2のリン酸化.
    第56回日本脂質生化学会. 近畿大学 東大阪キャンパス, 東大阪, 6月, 2014.
  4. 垂井 愛, 進藤 英雄, 森本 亮, 原山 武士, 橋立 智美, 熊谷 和夫, 長野 哲雄, 長瀬 隆英, 清水 孝雄.
    High-throughput screeningによるPAF生合成酵素（LPCAT2）阻害剤の同定.
    第56回日本脂質生化学会. 近畿大学 東大阪キャンパス, 東大阪, 6月, 2014.
  5. 山口 賢彦, 比嘉 涼子, 山崎 泰広, 五十里 彰, 石井 聡, 三輪 匡男, 清水 孝雄, 菅谷 純子.
    脂肪組織の慢性炎症化過程に関わる血小板活性化因子の機能解析.
    第56回日本脂質生化学会. 近畿大学 東大阪キャンパス, 東大阪, 6月, 2014.
  6. 菱川 大介.
    新規肺胞腔内分泌タンパク質Sec14-like 3の生化学的機能解析.
    第13回 肺サーファクタント分子病態研究会. 札幌医科大学 記念ホール, 札幌, 6月, 2014.
  7. 進藤 英雄, 森本 亮, 垂井 愛, 衛藤 樹, 原山 武士, 清水 孝雄.
    生体膜リン脂質多様性形成メカニズム.
    第87回日本生化学会大会. 国立京都国際会館, 京都, 10月, 2014.
  8. 菱川 大介, 進藤 英雄, 原山 武士, 小笠原 理恵, 諏訪部 章, 清水 孝雄.
    新規肺胞腔内脂質結合タンパク質Sec14-like 3の生化学的機能解析.
    第87回日本生化学会大会. 国立京都国際会館, 京都, 10月, 2014.
  9. 吉田 憲司, 北 芳博, 徳岡 涼美, 崎村 建司, 狩野 方伸, 清水 孝雄.
    モノアシルグリセロールリパーゼ欠損は高脂肪食負荷誘導性肥満を抑制する.
    第87回日本生化学会大会. 国立京都国際会館, 京都, 10月, 2014.
  10. 衛藤 樹, 橋本 唯史, 進藤 英雄, 岩坪 威, 清水 孝雄.
    ドコサヘキサエノイル-CoA（DHA-CoA）特異的新規リゾホスファチジン酸アシル転移酵素LPAAT4の同定およびアルツハイマー病との関連
    についての解析.
    第87回日本生化学会大会. 国立京都国際会館, 京都, 10月, 2014.
  11. 北 芳博, 吉田 憲司, 徳岡 涼美, 浜野 文三江, 山崎 真弥, 崎村 建司, 狩野 方伸, 清水 孝雄.
    発熱応答にはモノアシルグリセロールリパーゼ依存的なプロスタグランジンE2産生が必要である.
    第87回日本生化学会大会. 国立京都国際会館, 京都, 10月, 2014.
  12. 徳岡 涼美, 北 芳博, 山田 真希, 清水 孝雄.
    3液グラジエントクロマトグラフィーを用いた高速選択反応モニタリング（SRM）質量分析法によるリン脂質プロファイリングメソッドの開発.
    第87回日本生化学会大会. 国立京都国際会館, 京都, 10月, 2014.
  13. 進藤 英雄.
    生体膜リン脂質脂肪酸多様性形成メカニズムの解析.
    第2回JFAS(Japan/Joy of Fatty Acids Secrets/Society). 東京, 2月, 2015.
  14. 進藤 英雄.
    生体膜脂質の多様性形成と多様な役割.
    第9回レドックス・ライフイノベーションシンポジウム. 理化学研究所横浜キャンパス, 横浜, 3月, 2015.

著書・総説

総説－英文

  1. Hishikawa D, Hashidate T, Shimizu T, Shindou H.
    Diversity and function of membrane glycerophospholipids generated by the remodeling pathway in mammalian cells.
    J. Lipid Res. 55:799-807, 2014.

その他

業績
国立国際医療研究センター
シスチノーチの広場
ページの先頭へ戻る