- Increased Frequency of Dysfunctional Siglec-7 - CD57 + PD-1 + Natural Killer Cells in Patients With
- Applicability of APRI and FIB-4 as a transition indicator of liver fibrosis in patients with chronic
- Macrophages as a source of fibrosis biomarkers for non-alcoholic fatty liver disease
- Hepatocyte ploidy and pathological mutations in hepatocellular carcinoma: impact on oncogenesis and
- Impact of Immune Reconstitution-induced Hepatic Flare on HBsAg Loss in HBV/HIV-1-Coinfected Patients
- Serum milk fat globule-EGF factor 8 (MFG-E8) as a diagnostic and prognostic biomarker in patients wi
- A novel Ancestral Beijing sublineage of Mycobacterium tuberculosis suggests the transition site to M
- The association of integration patterns of human papilloma virus and single nucleotide polymorphisms
- Identification of HLA-DRB1*04:10 allele as risk allele for Japanese moyamoya disease and its associa
- Quality control project of NGS HLA genotyping for the 17th International HLA and Immunogenetics Work
- Genome-wide association study confirming the association of NAT2 with susceptibility to anti-tubercu
- Integrative genome analysis identified the KANNO blood group antigen as prion protein
- HLA-VBSeq v2: Improved HLA-calling accuracy with full-length Japanese class-I panel
- Analysis of whole Y-chromosome sequences reveals the Japanese population history in the Jomon period
- Bonemorphogenetic protein 4 provides cancer-supportive phenotypes to liver fibroblasts in patients w
- A 12-kb structural variation in progressive myoclonic epilepsy was newly identified by long-read who
- Changes in the quality of diabetes care in Japan between 2007 and 2015: A repeated cross-sectional s
- Hepatic Sdf2l1 controls feeding-induced ER stress and regulates metabolism
- The Ga12/13-coupled receptor, LPA4 limits proper adipose tissue expansion and remodeling in diet-ind
- Monoacylglycerol lipase deficiency affects diet-induced obesity, fat absorption, and feeding behavio
- Lysophosphatidic acid receptor, LPA6, regulates endothelial blood-brain barrier function: Implicatio
- Stepwise phosphorylation of leukotriene B4 receptor 1 defines cellular responses to leukotriene B4.
- Na+-mimicking ligands stabilize the inactive state of leukotriene B4 receptor BLT1
- Lysophosphatidic Acid Acyltransferase 3 Incorporates Docosahexaeneoic Acid into Skeletal Muscle Cell
- Cytokine and chemokine signatures associated with hepatitis B surface antigenloss in hepatitis B pat
- Phylogenetic and phylodynamic analysis of hepatitis C virus subtype 1a in Okinawa, Japan.
- Hepatitis B virus reactivation in patients with rheumatoid arthritis: Analysis of the National Datab
- Key HLA-DRB1-DQB1 haplotypes and role of the BTNL2 gene for response to a hepatitis B vaccine. Hepat
- Lnk/Sh2b3 regulates adipose inflammation and glucose tolerance through group 1 ILCs.
- Nr4a receptors regulate development and death of labile Treg precursors to prevent generation of pat
- Elimination of eosinophils using anti-IL-5 receptor alpha antibodies effectively suppresses IL-33-me
- Cyclosporin A indirectly attenuates activation of group 2 innate lymphoid cells in papain-induced lu
- Cytokine and chemokine signatures associated with hepatitis B surface antigen loss in hepatitis B pa
- PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimising gluconeoge
- A Glycomarker for Short-term Prediction of Hepatocellular Carcinoma: A Longitudinal Study With Seria
- Urinary afamin levels are associated with the progression of diabetic nephropathy
- Highly Sensitive Glycan Profiling of Hepatitis B Viral Particles and a Simple Method for Dane Partic
- Safety, Tolerability, and Preliminary Efficacy of the Anti-Fibrotic Small Molecule PRI-724, a CBP/
- The Effects of Laparoscopic Sleeve Gastrectomy with Duodenojejunal Bypass on Japanese Patients with
- HCV phylogenetic signature and prevalence of pretreatment NS5A and NS5B NI-Resistance associated sub
- Metabolic surgery for inadequately controlled type 2 diabetes in nonseverely obese Japanese: a prosp
- The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in
- Thioacetamideinduced hepatic fibrosis in the common marmoset
- De Novo Macrocyclic Peptide Inhibitors of Hepatitis B Virus Cellular Entry.
- Guidelines for clinical evaluation of chronic kidney disease : AMED research on regulatory science o
- Sofosbuvir- velpatasvir plus ribavirin in Japanese patients with genotype 1 or 2 hepatitis C who fai
- Bariatric and metabolic surgery in Asia: Where are we, and where are we going?
- Frequency and Characteristics of Occult Hepatitis B Infection Among Hepatocellular Carcinoma Patient
- Characteristics and clinical course of type 1 diabetes mellitus related to anti-programmed cell deat
- Association Between High Levels of Hepatitis B Core Antibody and Seroclearance of Hepatitis B e Anti
- Predictive performance of a genetic risk score using 11 susceptibility alleles for the incidence of
- Introduction of the TERT and BMI1 genes into murine dermal papilla cells ameliorates hair inductive
- Genome-wide association study identified new susceptible genetic variants in HLA class I region for
- Optical clearing of the pancreas for visualization of mature β-cells and vessels in mice
- Diffusion-weighted magnetic resonance imaging in the pancreas of fulminant type 1 diabetes
- Herpetiform pemphigus with characteristic transmission electron microscopic findings of various-size
- A type 2 diabetes-associated SNP in KCNQ1 (rs163184) modulates the binding activity of the locus for
- Functional association of cellular microtubules with viral capsid assembly supports efficient hepati
- Oncostatin M causes liver fibrosis by regulating cooperation between hepatic stellate cells and macr
- Mac-2 binding protein glycan isomer (M2BPGi) is a new serum biomarker for assessing liver fibrosis:
- NS5A resistance-associated substitutions in patients with genotype 1 hepatitis C virus: Prevalence a
- Sirt2 facilitates hepatic glucose uptake by deacetylating glucokinase regulatory protein
- Circulating ferritin concentrations are differentially associated with serum adipokine concentration
- Circadian clock regulates hepatic polyploidy by modulating Mkp1Erk1/2 signaling pathway
- Reduced therapeutic effect of antiviral drugs in patients with hepatitis B virus reactivation after
- A microRNA screen reveals that elevated hepatic ectodysplasin A expression contributes to obesity-in
- Effect of an intensified multifactorial intervention on cardiovascular outcomes and mortality in typ
- Kimura H, Suzuki M, Konno S, Shindou H, Shimizu T, Nagase T, Miyazaki T, Nishimura M.
Orchestrating Role of Apoptosis Inhibitor of Macrophage in the Resolution of Acute Lung Injury.
J Immunol. 2017 Dec 1;199(11):3870-3882. - Low incidence of hepatitis B virus reactivation and subsequent hepatitis in patients with chronic he
- Bone morphogenetic protein signaling governs biliary-driven liver regeneration in zebrafish through
- Investigating the Hepatitis B Virus Life Cycle Using Engineered Reporter Hepatitis B Viruses.
- Serum Levels of M2BPGi as Short-Term Predictors of Hepatocellular Carcinoma in Untreated Chronic Hep
- Quantitative assessment of liver fibrosis reveals a nonlinear association with fibrosis stage in non
- Pleckstrin homologylike domain family A, member 3 (PHLDA3) deficiency improves islets engraftment th
- Clinical significance of BRAF non-V600E mutations on the therapeutic effects of anti-EGFR monoclonal
- Methods for Microencapsulated Porcine Islet Production.
- Microencapsulation in Clinical Islet Xenotransplantation.
- Interferon-free therapy with direct acting antivirals for HCV/HIV-1 co-infected Japanese patients wi
- Alleviation of lipopolysaccharide/dgalactosamineinduced liver injury in leukocyte cellderived chemot
- Proteomic analysis of serum biomarkers for prediabetes using the Long-Evans Agouti rat, a spontaneou
- Human Leukocyte Antigen Variants and Risk of Hepatocellular Carcinoma Modified by HCV Genotypes: A G
- Role of HLA-DP and HLA-DQ on the clearance of hepatitis B virus and the risk of chronic infection in
- Serum Wisteria Floribunda Agglutinin-Positive Sialylated Mucin 1 as a Marker of Progenitor/Biliary F
- A human PSMB11 variant affects thymoproteasome processing and CD8+ T cell production.
- Pro-angiogenic TIE-2-expressing monocytes/TEMs as a biomarker of the effect of sorafenib in patients
- Shoji H, Yoshio S, Mano Y, Doi H, Sugiyama M, Osawa Y, Kimura K, Arai T, Itokawa N, Atsukawa M, Aoki Y, Fukai M, Taketomi A, Mizokami M, Kanto T.
Pro-angiogenic TIE-2-expressing monocytes/TEMs as a biomarker of the effect of sorafenib in patients with advanced hepatocellular carcinoma.
Int J Cancer. 2017 Sep 1;141(5):1011-1017. - Suppressive Effects of Mesenchymal Stem Cells in Adipose Tissue on Allergic Contact Dermatitis
- CD206(+) M2like macrophages regulate systemic glucose metabolism by inhibiting proliferation of adip
- Shindou H, Shiraishi S, Tokuoka SM, Takahashi Y, Harayama T, Abe T, Bando K, Miyano K, Kita Y, Uezono Y, Shimizu T.
Relief from neuropathic pain by blocking of the platelet-activating factor-pain loop.
FASEB J. 2017 Jul;31(7):2973-2980. - Suppression of HBV replication by the expression of nickase- and nuclease dead-Cas9.
- Shindou H, Koso H, Sasaki J, Nakanishi H, Sagara H, Nakagawa KM, Takahashi Y, Hishikawa D, Iizuka-Hishikawa Y, Tokumasu F, Noguchi H, Watanabe S, Sasaki T, Shimizu T.
Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells.
J Biol Chem. 2017 Jul 21;292(29):12054-12064. - Iizuka-Hishikawa Y, Hishikawa D, Sasaki J, Takubo K, Goto M, Nagata K, Nakanishi H, Shindou H, Okamura T, Ito C, Toshimori K, Sasaki T, Shimizu T.
Lysophosphatidic acid acyltransferase 3 tunes the membrane status of germ cells by incorporating docosahexaenoic acid during spermatogenesis.
J Biol Chem. 2017 Jul 21;292(29):12065-12076. - Dual Regulation of Gluconeogenesis by Insulin and Glucose in the Proximal Tubules of the Kidney
- Virological and Clinical Characteristics of Hepatitis B Virus Genotype A.
- YAP determines the cell fate of injured mouse hepatocytes in vivo
- Genome-Wide Association Study Identifies Risk Variants for Lichen Planus in Patients With Hepatitis
- Takeda T, Komiya Y, Koga T, Ishida T, Ishii Y, Kikuta Y, Nakaya M, Kurose H, Yokomizo T, Shimizu T, Uchi H, Furue M, Yamada H.
Dioxin-induced increase in leukotriene B4 biosynthesis through the aryl hydrocarbon receptor and its relevance to hepatotoxicity owing to neutrophil infiltration.
J Biol Chem. 2017 Jun 23;292(25):10586-10599. - Causes of death in Japanese patients with diabetes based on the results of a survey of 45,708 cases
- Plasma adiponectin levels, ADIPOQ variants, and incidence of type 2 diabetes: A nested casecontrol s
- Expression and localization of sterile alpha motif domain containing 5 is associated with cell type
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- 感染症, 糖尿病・代謝性疾患ならびに肝炎・免疫疾患の発症機序の解明につながる基礎的研究をはじめ、
先駆的な診断・治療法の開発を目指す橋渡し研究ならびに臨床研究を行い、それらの成果を通じて国際社会に貢献すること。
- 新興・再興感染症及びエイズ等の感染症
- 糖尿病・代謝性疾患
- 肝炎・免疫疾患
研究所
糖尿病研究センター
肝炎・免疫研究センター
国際ウイルス感染症研究センター
プロジェクト研究
